Genetic diversity of avian infectious bronchitis coronavirus strains isolated in China between 1995 and 2004.
Genetic diversity of avian infectious bronchitis coronavirus strains isolated in China between 1995 and 2004.
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DOI：
10.1007/s00705-005-0695-6
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发表时间：
2006-06
影响因子：
2.7
通讯作者：
Tong GZ
中科院分区：
文献类型：
--
作者：
Liu SW;Zhang QX;Chen JD;Han ZX;Liu X;Feng L;Shao YH;Rong JG;Kong XG;Tong GZ
从1995 ~ 2004年我国鸡群中分离到26株鸡传染性支气管炎病毒（IBV）。并与26株国内参考毒株和5株国外毒株进行了比较。将中国IBV分为7个基因型，主要致病性为肾。14个中国IBV分离株均为基因型I，彼此之间的进化距离较小。基因型II包括20世纪90年代在中国分离的6株。基因型III包括8个中国分离株，显示与韩国IBV分离株的密切关系。另外8个IBV分离株聚在基因型IV，并表现出较大的进化距离。马萨诸塞州血清型于20世纪90年代在中国出现，并处于单独的基因型中。HN 99和CK/CH/LHN/00 I可能是疫苗株的再分离株，聚为基因VI型。4个中国IBV分离株形成了另一个基因型，与其他中国IBV基因型（基因型VII）具有较大的进化距离。同一基因型的IBV氨基酸序列相似性大于90%，而不同基因型的IBV氨基酸序列相似性大多小于90%。结果表明，中国的IBV来自疫苗接种前存在的IBV种群和通过活疫苗引入的病毒的遗传变化。IBV在中国存在着多种遗传差异。
Twenty-six avian infectious bronchitis (IB) viruses (IBV) were isolated from outbreaks in chickens in China between 1995 and 2004. They were characterized by comparison with twenty-six Chinese reference strains and five other IBV strains. Chinese IBVs, which were mainly nephropathogenic, were placed into seven genotypes. Fourteen Chinese IBV isolates were placed in genotype I, having small evolutionary distances from each other. Genotype II included 6 strains that were isolated in the 1990s in China. Genotype III consisted of eight Chinese isolates that showed close relationship with Korean IBV isolates. Another eight IBV isolates clustered in genotype IV and showed larger evolutionary distances. The Massachusetts serotype was present in China in 1990s and was in a separate genotype. Two isolates, HN99 and CK/CH/LHN/00I, which might be a reisolation of vaccine strains, clustered into genotype VI. Four Chinese IBV isolates formed another genotype and showed larger evolutionary distances from other Chinese IBV genotypes (genotype VII). IBVs in same genotypes showed more than 90% amino acid sequence similarities, whereas most of the viruses in different genotypes showed less than 90%. The results showed that IBVs in China came from genetic changes both in IBV populations that existed before the advent of vaccination and in the viruses that were introduced through live vaccines. IBVs showing various genetic differences are cocirculating in China.
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