Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006.
Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006.
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DOI：
10.1016/j.metabol.2011.09.003
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发表时间：
2012-04
影响因子：
9.8
通讯作者：
Gurka, Matthew J.
中科院分区：
文献类型：
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作者：
DeBoer, Mark D.;Dong, Lili;Gurka, Matthew J.
在青少年中，尿酸与胰岛素抵抗、高血压和代谢综合征(METS)有关，而在成年人中，高尿酸水平是心血管疾病和糖尿病的独立危险因素。确定尿酸与蛋氨酸代谢综合征的关系在青少年中是否因种族/民族和性别而异。我们使用线性回归来评估尿酸和其他甲硫氨酸相关的临床和实验室指标之间的关系，在参加国家健康和营养评估调查(1999-2006)的3,296名12-19岁的非西班牙裔白人、非西班牙裔黑人和西班牙裔青少年中进行。总体而言，在三个种族/民族中，非西班牙裔白人男性和女性的尿酸水平最高。在每个种族/民族群体中，患有METS的青少年的尿酸水平高于不患有METS的青少年。然而，与蛋氨酸水平相关的尿酸水平增加的程度因种族和性别而异。在男性中，甲硫氨酸与非西班牙裔白人中尿酸的增加幅度最大。然而，在女性中，与METS相关的尿酸在非白人中的增幅最大。非西班牙裔白人女性的尿酸水平与METS相关变量之间的相关性程度最低。在非西班牙裔白人女性中，尿酸水平与胰岛素水平没有相关性。这些数据表明，尿酸和蛋氨酸代谢综合征之间的关系因种族/民族和性别而异。特别是，非西班牙裔白人男性表现出很强的相关性，而非西班牙裔白人女性表现出相对较差的尿酸和METS相关因素之间的相关性。这些数据可能对使用尿酸作为青少年未来风险的标志有影响。
Among adolescents uric acid is associated with insulin resistance, hypertension and the metabolic syndrome (MetS) and in adults high uric acid levels are an independent risk factor for cardiovascular disease and diabetes. Determine whether the relationship of uric acid with MetS varies in adolescents by race/ethnicity and gender. We used linear regression to evaluate associations between uric acid and other MetS-associated clinical and laboratory measures among 3,296 non-Hispanic-white, non-Hispanic-black and Hispanic adolescents age 12–19y participating in the National Health and Nutrition Evaluation Survey (1999–2006). Overall, non-Hispanic-white males and females had the highest uric acid levels among the three racial/ethnic groups. In each racial/ethnic group there were higher uric acid levels for those adolescents with vs. without MetS. However, the extent of the MetS-related increase in uric acid level varied by race and gender. Among males, MetS was associated with the greatest increases in uric acid among non-Hispanic whites. However, among females, the MetS-related increase in uric acid was greatest among non-whites. Non-Hispanic-white females exhibited the lowest degrees of correlation between levels of uric acid and MetS-associated variables. Uric acid levels did not correlate with insulin levels in non-Hispanic-white females. These data suggest the relationship between uric acid and MetS varies by race/ethnicity and gender. In particular, non-Hispanic-white males exhibit a strong relationship and non-Hispanic-white females exhibit a relatively poor correlation between uric acid and MetS-related factors. These data may have implications for the use of uric acid as a marker of future risk among adolescents.
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影响因子：
9.8
作者：
Liu, Pei-Wen;Chang, Tsui-Yen;Chen, Jong-Dar
通讯作者：
Chen, Jong-Dar
影响因子：
2.1
作者：
DeBoer, Mark D.;Gurka, Matthew J.
通讯作者：
Gurka, Matthew J.
影响因子：
13.2
作者：
Iseki, K;Ikemiya, Y;Takishita, S
通讯作者：
Takishita, S
影响因子：
16.2
作者：
Li, Chaoyang;Ford, Earl S.;Reaven, Gerald M.
通讯作者：
Reaven, Gerald M.
DOI：
10.1001/archpediatrics.2009.3
发表时间：
2009-04-01
影响因子：
--
作者：
Johnson, William D.;Kroon, Jolanda J. M.;Katzmarzyk, Peter T.
通讯作者：
Katzmarzyk, Peter T.