CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.
CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool.
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DOI：
10.1084/jem.20030916
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发表时间：
2003-11-03
影响因子：
15.3
通讯作者：
Borst, J
中科院分区：
文献类型：
--
作者：
Hendricks, J;Xiao, YL;Borst, J
与CD 28一样，CD 27与T细胞受体协同作用以支持T细胞扩增。使用CD 27 −/−小鼠，我们已经证明了CD 27决定了对流感病毒的初级和记忆T细胞反应的大小。在这里，我们使用CD 27 −/−、CD 28 −/−和CD 27/CD 28 −/−小鼠，研究了CD 27和CD 28对病毒特异性效应T细胞库产生及其在感染部位（肺）建立的相对贡献。我们发现，原发性和记忆性CD 8 + T细胞对流感病毒的反应依赖于两种受体的共同贡献。在初次应答中，CD 27和CD 28对引流淋巴结中病毒特异性T细胞扩增的影响程度相似。CD 27是病毒特异性T细胞在肺中积累的主要决定因素，因为它可以在CD 28 −/−小鼠中维持这种反应。与CD 28不同，CD 27不影响细胞周期活性，但在引发部位的连续几轮分裂中促进活化T细胞的存活，并且在感染部位也可能如此。CD 27被发现在分裂开始时拯救CD 28 −/− T细胞免于死亡，解释了它在缺乏CD 28的情况下支持T细胞应答的能力。
CD27, like CD28, acts in concert with the T cell receptor to support T cell expansion. Using CD27−/− mice, we have shown earlier that CD27 determines the magnitude of primary and memory T cell responses to influenza virus. Here, we have examined the relative contributions of CD27 and CD28 to generation of the virus-specific effector T cell pool and its establishment at the site of infection (the lung), using CD27−/−, CD28−/−, and CD27/CD28−/− mice. We find that primary and memory CD8+ T cell responses to influenza virus are dependent on the collective contribution of both receptors. In the primary response, CD27 and CD28 impact to a similar extent on expansion of virus-specific T cells in draining lymph nodes. CD27 is the principle determinant for accumulation of virus-specific T cells in the lung because it can sustain this response in CD28−/− mice. Unlike CD28, CD27 does not affect cell cycle activity, but promotes survival of activated T cells throughout successive rounds of division at the site of priming and may do so at the site of infection as well. CD27 was found to rescue CD28−/− T cells from death at the onset of division, explaining its capacity to support a T cell response in absence of CD28.
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DOI：
10.1084/jem.190.9.1319
发表时间：
1999-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Haanen JB;Wolkers MC;Kruisbeek AM;Schumacher TN
通讯作者：
Schumacher TN
DOI：
10.1084/jem.191.12.2031
发表时间：
2000-06-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dahl AM;Klein C;Andres PG;London CA;Lodge MP;Mulligan RC;Abbas AK
通讯作者：
Abbas AK
影响因子：
32.4
作者：
Arens, R;Tesselaar, K;van Lier, RAW
通讯作者：
van Lier, RAW
影响因子：
5.4
作者：
GRAVESTEIN, LA;BLOM, B;LOENEN, WAM
通讯作者：
LOENEN, WAM
影响因子：
30.5
作者：
Hendriks, J;Gravestein, LA;Borst, J
通讯作者：
Borst, J