T helper type (Th1/Th2) responses to SARS-CoV-2 and influenza A (H1N1) virus: From cytokines produced to immune responses.

T helper type (Th1/Th2) responses to SARS-CoV-2 and influenza A (H1N1) virus: From cytokines produced to immune responses.
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DOI:
10.1016/j.trim.2021.101495
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发表时间:
2022-03
影响因子:
1.5
通讯作者:
Hasanpour-Dehkordi A
Hasanpour-Dehkordi A
中科院分区:
医学4区
文献类型:
--
作者:
Aleebrahim-Dehkordi E;Molavi B;Mokhtari M;Deravi N;Fathi M;Fazel T;Mohebalizadeh M;Koochaki P;Shobeiri P;Hasanpour-Dehkordi A

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辅助性T细胞(Th细胞)产生的细胞因子在人体防御病毒中起着至关重要的作用。1型辅助性T细胞(Th1)对宿主防御细胞内病原体至关重要,而2型辅助性T细胞(Th2)被认为对蠕虫寄生虫消除猪源性甲型H1N1流感病毒至关重要。甲型H1N1流感病毒在2009年导致流行,并通过人际传播在全球迅速传播。由严重急性呼吸系统综合征冠状病毒2型(SARS-CoV-2)引起的2019冠状病毒病(COVID-19)已在2020年引发全球大流行,对公众健康构成严重威胁。在流感和SARS-CoV-2流行和大流行期间,肺部免疫病理是导致死亡的主要原因。流感和SARS-CoV-2会导致肺部细胞因子水平升高。特定细胞因子水平的不足和高水平都会产生副作用。在这篇文献综述文章中,我们想比较Th1和Th2细胞在SARS-CoV-2和H1N1中的反应。
Cytokines produced by T helper cells (Th cells) have essential roles in the body's defense against viruses. Type 1 T helper (Th1) cells are essential for the host defense toward intracellular pathogens while T helper type 2 (Th2) cells are considered to be critical for the helminthic parasites' elimination swine-origin influenza A (H1N1) virus, a disease led to an epidemic in 2009 and rapidly spread globally via human-to-human transmission. Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic in 2020 and is a serious threat to the public health. Pulmonary immunopathology is the leading cause of death during influenza and SARS-CoV-2 epidemics and pandemics. Influenza and SARS-CoV-2 cause high levels of cytokines in the lung. Both inadequate levels and high levels of specific cytokines can have side effects. In this literature review article, we want to compare the Th1 and Th2 cells responses in SARS-CoV-2 and H1N1.
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