Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines.

Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines.
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DOI:
10.3390/ijms23031706
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发表时间:
2022-02-01
影响因子:
5.6
通讯作者:
Upender RP
Upender RP
中科院分区:
生物学2区
文献类型:
--
作者:
Wei Z;Chen Y;Upender RP

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脂肪因子是一类不断发展的肽类或蛋白类激素,在全身代谢和代谢性疾病中起着重要作用。睡眠是能量代谢的重要组成部分,睡眠障碍与多种代谢紊乱有关。越来越多的证据表明,脂肪因子可能在睡眠障碍和全身代谢紊乱之间的密切联系中起着中介作用。在这篇综述中,我们简要地总结了一组选定的脂肪因子及其在代谢中的功能。此外,我们从最近的人类和动物研究中提供了这些脂肪因子及其在睡眠生理学和睡眠障碍中的作用的平衡概述。这些研究共同表明,脂肪因子在睡眠生理学和睡眠障碍中的功能可能在很大程度上是双重的:(1)脂肪因子在睡眠生理学和睡眠障碍中具有多方面的作用;(2)睡眠障碍反过来会影响脂肪因子的功能,可能导致全身代谢紊乱。
Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of metabolic disorders. Accumulating evidence suggests that adipokines may play a role in mediating the close association between sleep disorders and systemic metabolic derangements. In this review, we briefly summarize a group of selected adipokines and their identified function in metabolism. Moreover, we provide a balanced overview of these adipokines and their roles in sleep physiology and sleep disorders from recent human and animal studies. These studies collectively demonstrate that the functions of adipokine in sleep physiology and disorders could be largely twofold: (1) adipokines have multifaceted roles in sleep physiology and sleep disorders, and (2) sleep disturbance can in turn affect adipokine functions that likely contribute to systemic metabolic derangements.
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