Attentive brain states in infants with and without later autism.
Attentive brain states in infants with and without later autism.
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DOI：
10.1038/s41398-021-01315-9
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发表时间：
2021-03-30
影响因子：
6.8
通讯作者：
Jones EJH
中科院分区：
文献类型：
--
作者：
Gui A;Bussu G;Tye C;Elsabbagh M;Pasco G;Charman T;Johnson MH;Jones EJH
早期在社交环境中保持专注的大脑状态的困难可能会影响学习，并对社交发展产生级联效应。我们在有自闭症谱系障碍（ASD）家族史的8个月大的婴儿（FH, n = 91）和没有（noFH, n = 40）中使用多通道脑电图在面部/非面部范式下研究了这种可能性。在3岁时被诊断为ASD的FH婴儿（FH-ASD, n = 19）、未被诊断为ASD的FH婴儿（FH- noasd, n = 72）和未被诊断为ASD的noFH婴儿（也未被诊断为noFH- noasd， n = 40）之间，比较了反映注意力投入的事件相关电位成分Nc。从noFH-noASD组中提取社会注意期间的“原型”微观状态，并检查其与后来的分类和维度结果的关系。机器学习被用来识别三岁时最能预测ASD和社会适应技能的微观状态特征。结果表明，虽然大脑状态时间的测量与ASD的分类结果有关，但大脑状态强度与社会功能的维度测量有关。具体来说，FH-ASD组的Nc潜伏期比其他组短，对面孔的注意微状态反应的持续时间为分类结果预测提供了信息。直接凝视与非社会控制刺激的Nc振幅差的减小以及对面孔的注意微状态的强度有助于预测社交技能的维度变化。综上所述，这提供了非典型注意投入先于社会化困难出现的一致证据，并表明利用全脑激活的时空特征来定义婴儿时期的大脑状态，为理解导致ASD的神经发育机制提供了重要的新途径。
Early difficulties in engaging attentive brain states in social settings could affect learning and have cascading effects on social development. We investigated this possibility using multichannel electroencephalography during a face/non-face paradigm in 8-month-old infants with (FH, n = 91) and without (noFH, n = 40) a family history of autism spectrum disorder (ASD). An event-related potential component reflecting attention engagement, the Nc, was compared between FH infants who received a diagnosis of ASD at 3 years of age (FH-ASD; n = 19), FH infants who did not (FH-noASD; n = 72) and noFH infants (who also did not, hereafter noFH-noASD; n = 40). ‘Prototypical’ microstates during social attention were extracted from the noFH-noASD group and examined in relation to later categorical and dimensional outcome. Machine-learning was used to identify the microstate features that best predicted ASD and social adaptive skills at three years. Results suggested that whilst measures of brain state timing were related to categorical ASD outcome, brain state strength was related to dimensional measures of social functioning. Specifically, the FH-ASD group showed shorter Nc latency relative to other groups, and duration of the attentive microstate responses to faces was informative for categorical outcome prediction. Reduced Nc amplitude difference between faces with direct gaze and a non-social control stimulus and strength of the attentive microstate to faces contributed to the prediction of dimensional variation in social skills. Taken together, this provides consistent evidence that atypical attention engagement precedes the emergence of difficulties in socialization and indicates that using the spatio-temporal characteristics of whole-brain activation to define brain states in infancy provides an important new approach to understanding of the neurodevelopmental mechanisms that lead to ASD.
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影响因子：
4.9
作者：
Dawson G;Bernier R;Ring RH
通讯作者：
Ring RH
影响因子：
3.7
作者：
Bedford R;Pickles A;Gliga T;Elsabbagh M;Charman T;Johnson MH;BASIS Team
通讯作者：
BASIS Team
影响因子：
4.9
作者：
Girault, Jessica B.;Swanson, Meghan R.;Shen, M.
通讯作者：
Shen, M.
影响因子：
7.6
作者：
Green, Jonathan;Pickles, Andrew;Johnson, Mark
通讯作者：
Johnson, Mark
DOI：
10.1016/j.cub.2011.12.056
发表时间：
2012-02-21
期刊：
Current biology : CB
影响因子：
--
作者：
Elsabbagh M;Mercure E;Hudry K;Chandler S;Pasco G;Charman T;Pickles A;Baron-Cohen S;Bolton P;Johnson MH;BASIS Team
通讯作者：
BASIS Team