Social attention: a possible early indicator of efficacy in autism clinical trials.

Social attention: a possible early indicator of efficacy in autism clinical trials.
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DOI:
10.1186/1866-1955-4-11
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发表时间:
2012-05-17
影响因子:
4.9
通讯作者:
Ring RH
Ring RH
中科院分区:
医学2区
文献类型:
--
作者:
Dawson G;Bernier R;Ring RH

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几十年来,研究人员一直试图澄清自闭症患者社交沟通障碍的本质,强调受损或非典型的“社交注意力”是一个关键的可测量结构,有助于定义社交沟通的核心障碍。本文就孤独症患者的社会注意缺陷及其与社会奖励相关神经回路缺陷的关系进行综述。我们提供了一个框架来考虑社会注意力作为早期行为干预反应的潜在调节或中介,以及作为旨在解决自闭症社会障碍的行为和/或药物治疗效果的早期指标。
For decades, researchers have sought to clarify the nature of the social communication impairments in autism, highlighting impaired or atypical 'social attention' as a key measurable construct that helps to define the core impairment of social communication. In this paper, we provide an overview of research on social attention impairments in autism and their relation to deficiencies in neural circuitry related to social reward. We offer a framework for considering social attention as a potential moderator or mediator of response to early behavioral intervention, and as an early indicator of efficacy of behavioral and/or pharmacological treatments aimed at addressing the social impairments in autism.
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