Objective measurement of subjective tinnitus using the acoustic change complex.
Objective measurement of subjective tinnitus using the acoustic change complex.
复制标题
DOI：
10.1371/journal.pone.0188268
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Lee HJ
中科院分区：
文献类型：
--
作者：
Han JH;Won JY;Hong SK;Kim JH;Kim ES;Kim HJ;Lee HJ
目前，主观感音神经性耳鸣的诊断尚无客观方法。最近，声学变化复合体(ACC)被用来评价神经对声音的检测。因此，本研究的目的是检查ACC是否能反映皮层对与耳鸣频率相匹配的声音的检测和辨别。我们假设耳鸣患者改变与耳鸣频率相匹配的刺激的ACC会降低，因为耳鸣干扰了对声学变化的感知。为了验证这一假设，对听力正常的耳鸣患者和对照组的96耳进行了测试。耳鸣患者中耳鸣频率为8 kHz的33耳为耳鸣组，无耳鸣病史的63耳为对照组。对于4 kHz非耳鸣匹配频率，测试了耳鸣患者(n=17)和非耳鸣患者(n=47)的子集。声刺激是总持续时间为500ms的纯音，包括在前250ms中的1 kHz音调和在后250ms中8 kHz或4 kHz的第二音调。分别根据8 kHz或4 kHz变化刺激引起的N1‘-P2’复合波的幅度和初始1 kHz背景刺激引起的N1-P2复合波的幅度，计算出ACC的归一化幅度(NaACC)。结果表明，耳鸣组对8 kHz刺激的NAACC明显小于正常对照组的4 kHz和8 kHz刺激。此外，在耳鸣组，4 kHz的NAACC比8 kHz的NAACC更大。受试者工作特性(ROC)曲线分析显示，在伦敦大学学院对8 kHz的NAACC进行了相当程度的诊断效果。总体而言，我们的结果表明，ACC对与耳鸣频率相匹配的改变刺激可以提供频率特异性耳鸣的客观测量。
At present, there is no objective method for diagnosing subjective sensorineural tinnitus. Recently, the acoustic change complex (ACC) has been used to evaluate neural detection of sounds. Thus, the present study aimed to examine whether the ACC can reflect cortical detection and discrimination of sounds matched with tinnitus frequencies. We hypothesized that the ACC to change stimuli matched with tinnitus frequencies would be decreased in tinnitus patients because the tinnitus interferes with the perception of acoustic changes. To test the hypothesis, 96 ears of normal-hearing (NH) tinnitus patients and controls were tested. Among the tinnitus patients, 33 ears with a tinnitus frequency of 8 kHz constituted the tinnitus group, and the remaining 63 ears with no experience of tinnitus were allocated to the control group. For the 4 kHz non-tinnitus matched frequency, a subset of tinnitus (n = 17) and NH (n = 47) subjects was tested. The acoustic stimuli were pure tones with a total duration of 500 ms consisting of a 1 kHz tone in the first 250 ms and a second tone of either 8 kHz or 4 kHz in the latter 250 ms. The normalized amplitude of the ACC (naACC) was calculated separately for the amplitude of the N1’-P2’ complex evoked by an 8 kHz or 4 kHz change stimulus and for the amplitude of the N1-P2 complex elicited by the initial 1 kHz background stimulus. Our results showed that the naACC to an 8 kHz stimulus in the tinnitus group was significantly smaller than those to 4 kHz and 8 kHz in normal controls. Additionally, in the tinnitus group, the naACC to 4 kHz was greater compared to 8 kHz. The receiver operating characteristic (ROC) curve analysis conducted for naACC to 8 kHz at UCL revealed a fair degree of diagnostic efficacy. Overall, our results indicated that the ACC to a change stimulus matched with the tinnitus frequency can provide an objective measure of frequency-specific tinnitus.
登录
查看更多内容
影响因子：
3
作者：
Bharadwaj HM;Verhulst S;Shaheen L;Liberman MC;Shinn-Cunningham BG
通讯作者：
Shinn-Cunningham BG
影响因子：
2.1
作者：
Park, R. J.;Moon, J. D.
通讯作者：
Moon, J. D.
影响因子：
2.8
作者：
Eggermont, JJ;Komiya, H
通讯作者：
Komiya, H
影响因子：
1.9
作者：
JASTREBOFF, PJ;BRENNAN, JF;SASAKI, CT
通讯作者：
SASAKI, CT
影响因子：
2.7
作者：
Plack CJ;Barker D;Prendergast G
通讯作者：
Prendergast G