Effects of reward on spatial working memory in schizophrenia.
Effects of reward on spatial working memory in schizophrenia.
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DOI：
10.1037/abn0000369
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发表时间：
2018-10
影响因子：
4.6
通讯作者：
Anticevic A
中科院分区：
文献类型：
--
作者：
Cho YT;Lam NH;Starc M;Santamauro N;Savic A;Diehl CK;Schleifer CH;Moujaes F;Srihari VH;Repovs G;Murray JD;Anticevic A
奖励处理和认知在精神分裂症（SCZ）中被破坏，但这些过程如何相互作用尚不清楚。在SCZ中，奖励表征的缺陷可能会影响动机，目标导向的行为。为了验证这一点，我们研究了金钱奖励对SCZ患者空间工作记忆（WM）表现的影响。为了捕捉互补的效果，我们测试了生物药理学接地的神经药理学操作的计算模型到一个典型的额顶叶协会皮层微电路能够WM计算。SCZ患者（n=33）和健康对照受试者（HCS）（n=32）进行了空间WM任务与两个奖励操作：奖励线索之前，每次试验，或上下文之前的一个块的试验。WM性能进行了比较，大脑皮层电路模型进行前馈神经元兴奋，前馈GABA能抑制或经常性调制加强本地连接。结果表明，两组都改善了WM表现，以奖励每次试验前呈现的线索（HCS d=-0.62; SCZ d=-1.0），改善百分比与基线WM表现相关（r=0.472，p<0.001）。然而，在一组试验之前提供的奖励并没有改善SCZ患者的WM表现（d=0.01）。通过神经调节或前馈抑制加强局部连接，建模模拟实现了WM精度的提高。两者合计，这项工作表明，SCZ患者可以改善WM性能短期，但长期奖励，从而激励行为可能会受到限制的强度奖励表示，此外，基线WM性能。一个潜在的机制，短暂改善工作记忆的表现可能是加强当地的额顶叶微电路连接通过神经调制或前馈抑制驱动。
Reward processing and cognition are disrupted in schizophrenia (SCZ), yet how these processes interface is unknown. In SCZ, deficits in reward representation may affect motivated, goal-directed behaviors. To test this, we examined the effects of monetary reward on spatial working memory (WM) performance in patients with SCZ. To capture complimentary effects, we tested biophysically-grounded computational models of neuropharmacologic manipulations onto a canonical fronto-parietal association cortical microcircuit capable of WM computations. Patients with SCZ (n=33) and healthy control subjects (HCS) (n=32) performed a spatial WM task with two reward manipulations: reward cues presented prior to each trial, or contextually prior to a block of trials. WM performance was compared to cortical circuit models of WM subjected to feed-forward glutamatergic excitation, feed-forward GABAergic inhibition or recurrent modulation strengthening local connections. Results demonstrated that both groups improved WM performance to reward cues presented prior to each trial (HCS d=−0.62; SCZ d=−1.0), with percent improvement correlating with baseline WM performance (r=0.472, p<0.001). However, rewards presented contextually before a block of trials did not improve WM performance in patients with SCZ (d=0.01). Modeling simulations achieved improved WM precision through strengthened local connections via neuromodulation, or feed-forward inhibition. Taken together, this work demonstrates that patients with SCZ can improve WM performance to short-term, but not longer-term rewards—thus motivated behaviors may be limited by strength of reward representation, and, additionally, baseline WM performance. A potential mechanism for transiently improved WM performance may be strengthening of local fronto-parietal microcircuit connections via neuromodulation or feed-forward inhibitory drive.
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影响因子：
3.8
作者：
Chiew KS;Braver TS
通讯作者：
Braver TS
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作者：
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通讯作者：
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COHEN, JD;SERVANSCHREIBER, D
通讯作者：
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