7T quantitative magnetization transfer (qMT) of cortical gray matter in multiple sclerosis correlates with cognitive impairment.
7T quantitative magnetization transfer (qMT) of cortical gray matter in multiple sclerosis correlates with cognitive impairment.
复制标题
多发性硬化症患者皮质灰质的 7T 定量磁化传递 (qMT) 与认知障碍相关。
DOI：
10.1016/j.neuroimage.2019.116190
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发表时间：
2019-12
期刊：
影响因子：
5.7
通讯作者：
Smith SA
中科院分区：
文献类型：
--
作者：
McKeithan LJ;Lyttle BD;Box BA;O'Grady KP;Dortch RD;Conrad BN;Thompson LM;Rogers BP;Newhouse P;Pawate S;Bagnato F;Smith SA
认知障碍（CI）是多发性硬化症（MS）的主要表现，严重影响患者的生活质量。皮质灰质（cGM）损伤是脑损伤的重要因素，但常规MRI很难对其进行表征，更不用说定量MRI了，如定量磁化转移（qMT）。在这里，我们通过选择性反转恢复（SIR）方法在7T采用高分辨率qMT，该方法提供了组织大分子含量的组织特异性指标，如池大小比（PSR）和MT交换率（kmf）。这些指标可以代表预期的脱髓鞘发生在存在灰质损伤。我们利用选择性反演恢复（SIR） qMT，利用在7T多次反演（TI）下获得的定制的B1和B0鲁棒反演恢复（IR）序列，提供了大分子-体水相互作用的低SAR估计，并适合两池磁化交换模型。使用该序列，我们评估了复发缓解型多发性硬化症患者（N = 19）和健康志愿者（N = 37）的qMT指数，并得出了与认知障碍神经心理学测量的相关关联。我们发现MS患者cGM的kmf显著降低（15.5%,p = 0.002），与EDSS有独特的相关性（ρ = - 0.922, p = 0.0001），与认知表现有很强的相关性（ρ = - 0.602, p = 0.0082）。这些发现表明，MT交换率（kmf）可能是MS中与CI相关的cGM损伤的重要生物标志物。
Cognitive impairment (CI) is a major manifestation of multiple sclerosis (MS) and is responsible for extensively hindering patient quality of life. Cortical gray matter (cGM) damage is a significant contributor to CI, but is poorly characterized by conventional MRI let alone with quantitative MRI, such as quantitative magnetization transfer (qMT). Here we employed high-resolution qMT at 7T via the selective inversion recovery (SIR) method, which provides tissue-specific indices of tissue macromolecular content, such as the pool size ratio (PSR) and the rate of MT exchange (kmf). These indices could represent expected demyelination that occurs in the presence of gray matter damage. We utilized selective inversion recovery (SIR) qMT which provides a low SAR estimate of macromolecular-bulk water interactions using a tailored, B1 and B0 robust inversion recovery (IR) sequence acquired at multiple inversion times (TI) at 7T and fit to a two-pool model of magnetization exchange. Using this sequence, we evaluated qMT indices across relapsing-remitting multiple sclerosis patients (N = 19) and healthy volunteers (N = 37) and derived related associations with neuropsychological measures of cognitive impairment. We found a significant reduction in kmf in cGM of MS patients (15.5%, p = 0.002), unique association with EDSS (ρ = −0.922, p = 0.0001), and strong correlation with cognitive performance (ρ = −0.602, p = 0.0082). Together these findings indicate that the rate of MT exchange (kmf) may be a significant biomarker of cGM damage relating to CI in MS.
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影响因子：
5.7
作者：
Dortch, Richard D.;Moore, Jay;Li, Ke;Jankiewicz, Marcin;Gochberg, Daniel F.;Hirtle, Jane A.;Gore, John C.;Smith, Seth A.
通讯作者：
Smith, Seth A.
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Barkhof, F
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通讯作者：
Morris, Peter Gordon
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作者：
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通讯作者：
Munschauer, F
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作者：
Drew, Margaret A.;Starkey, Nicola J.;Isler, Robert B.
通讯作者：
Isler, Robert B.