Pathophysiological effects of dietary essential fatty acid balance on neural systems.

Pathophysiological effects of dietary essential fatty acid balance on neural systems.
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膳食必需脂肪酸平衡对神经系统的病理生理学影响。

DOI:
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发表时间:
1998
期刊:
Japanese Journal of Pharmacology
影响因子:
--
通讯作者:
Harumi Okuyama
Harumi Okuyama
中科院分区:
--
文献类型:
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作者:
Satoshi Yoshida;Akira Sato;Harumi Okuyama

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膳食脂肪酸平衡已被揭示影响神经功能以及慢性疾病,如癌症、脑和心血管疾病以及过敏性高反应性。本文就n-6和n-3脂肪酸对脑功能的病理生理作用作一综述。在存在n-6脂肪酸的情况下,长期n-3脂肪酸缺乏已被证明会影响学习行为,药物敏感性和视网膜功能。一些膜酶和离子通道功能已在实验动物中显示出由膜脂肪酸修饰调节。我们还总结了这些脂肪酸在饮食中对人类精神方面和脑部疾病的影响。虽然生物化学机制仍有待阐明,但膳食脂肪酸对神经网络影响的研究可能为阐明复杂的大脑功能提供重要线索。
Dietary fatty acid balance has been revealed to affect neural functions as well as chronic diseases such as cancer, cerebro- and cardiovascular diseases, and allergic hyper-reactivity. In this review, we focused on the pathophysiological effects of n-6 and n-3 fatty acids on brain functions. Long-term n-3 fatty acid deficiency in the presence of n-6 fatty acids has been shown to affect learning behavior, drug sensitivity and retinal functions. Some membrane enzymes and ion channel functions have been shown in experimental animals to be regulated by membrane fatty acid modifications. We also summarized the effects of these fatty acids in diets on human psychotic aspects and brain diseases. Although biochemical mechanisms remain to be elucidated, investigations on the effect of dietary fatty acids on neural networks may provide an important clue to clarify complex brain functions.
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