Switching fat from the periphery to bone marrow: why in Type I diabetes?
Switching fat from the periphery to bone marrow: why in Type I diabetes?
复制标题
将脂肪从外周转移到骨髓:为什么是 I 型糖尿病?
DOI:
10.1586/eem.09.3
复制
发表时间:
2009
影响因子:
3.2
通讯作者:
L. McCabe
中科院分区:
文献类型:
--
作者:
L. McCabe
Type I (T1) diabetes is characterized by hypoinsulinemia and hyperglycemia as a consequence of decreased glucose uptake by insulin-sensitive cells. When T1 diabe-tes is poorly controlled, weight loss occurs and is manifested by a decrease in both muscle and peripheral fat mass. This sug-gests that anabolic, tissue-building proc-esses are suppressed. Correspondingly, bone formation is decreased and can lead to bone loss in T1 diabetic humans and rodent models
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