Switching fat from the periphery to bone marrow: why in Type I diabetes?

Switching fat from the periphery to bone marrow: why in Type I diabetes?
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将脂肪从外周转移到骨髓:为什么是 I 型糖尿病?

DOI:
10.1586/eem.09.3
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发表时间:
2009
影响因子:
3.2
通讯作者:
L. McCabe
L. McCabe
中科院分区:
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文献类型:
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作者:
L. McCabe

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I型(T1)糖尿病的特征在于低胰岛素血症和高血糖症,这是由于胰岛素敏感细胞的葡萄糖摄取减少的结果。当T1型糖尿病控制不佳时,体重减轻发生,并表现为肌肉和外周脂肪量减少。这表明合成代谢和组织生成过程受到抑制。相应地,在T1糖尿病人和啮齿动物模型中,骨形成减少并可导致骨丢失
Type I (T1) diabetes is characterized by hypoinsulinemia and hyperglycemia as a consequence of decreased glucose uptake by insulin-sensitive cells. When T1 diabe-tes is poorly controlled, weight loss occurs and is manifested by a decrease in both muscle and peripheral fat mass. This sug-gests that anabolic, tissue-building proc-esses are suppressed. Correspondingly, bone formation is decreased and can lead to bone loss in T1 diabetic humans and rodent models
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