Neural mechanisms of semantic interference and false recognition in short-term memory.
Neural mechanisms of semantic interference and false recognition in short-term memory.
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DOI：
10.1016/j.neuroimage.2011.02.048
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发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Reuter-Lorenz, Patricia A.
中科院分区：
文献类型：
--
作者：
Atkins, Alexandra S.;Reuter-Lorenz, Patricia A.
几十年来，使用DRM范式的研究表明，情景记忆容易受到语义扭曲的影响，对这一现象的神经影像学研究表明，从长期记忆中提取真假的神经机制之间存在分离。最近，错误的短期记忆也被证明，错误识别与记忆编码不到5秒的意义相关的项目。语义干扰在短期记忆中也是明显的，例如相对于正确拒绝不相关的诱饵，正确拒绝相关的诱饵是缓慢的。本研究首次采用短时DRM范式对短时记忆中的错误再认和语义干扰进行了fMRI研究。结果显示，左侧腹外侧前额叶皮质（BA 45）的激活增加与语义干扰相关，并且这些增加与受试者的干扰行为测量之间存在显着相关性。此外，背外侧PFC的增加发生在相关的诱惑被正确拒绝与错误的记忆。与错误识别相比，真实识别与左梭状回的增加有关，这一发现与以下观点一致：增加的感知处理可以在短和长的保留间隔内区分真假识别。研究结果进行了讨论，在短期记忆中的干扰分辨率的当前模型，并建议，错误的短期识别发生的结果，前端介导的认知控制过程，裁定语义熟悉的支持准确的记忆检索失败。
Decades of research using the Deese-Roediger-McDermot (DRM) paradigm have demonstrated that episodic memory is vulnerable to semantic distortion, and neuroimaging investigations of this phenomenon have shown dissociations between the neural mechanisms subserving true and false retrieval from long-term memory. Recently, false short-term memories have also been demonstrated, with false recognition of items related in meaning to memoranda encoded less than 5 seconds earlier. Semantic interference is also evident in short-term memory, such that correct rejection of related lures is slowed relative to correct rejection of unrelated lures. The present research constitutes the first fMRI investigation of false recognition and semantic interference in short-term memory using a short-term DRM paradigm in which participants retained 4 semantic associates over a short 4 second filled retention interval. Results showed increased activation in the left mid-ventrolateral prefrontal cortex (BA45) associated with semantic interference, and significant correlations between these increases and behavioral measures of interference across subjects. Furthermore, increases in dorsolateral PFC occurred when related lures were correctly rejected versus falsely remembered. Compared with false recognition, true recognition was associated with increases in left fusiform gyrus, a finding consistent with the notion that increased perceptual processing may distinguish true from false recognition over both short and long retention intervals. Findings are discussed in relation to current models of interference resolution in short-term memory, and suggest that false short-term recognition occurs as a consequence of the failure of frontally-mediated cognitive control processes which adjudicate semantic familiarity in support of accurate mnemonic retrieval.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1037/a0019903
发表时间：
2010-09
影响因子：
2.6
作者：
Flegal, Kristin E.;Atkins, Alexandra S.;Reuter-Lorenz, Patricia A.
通讯作者：
Reuter-Lorenz, Patricia A.
DOI：
10.1073/pnas.96.14.8301
发表时间：
1999-07-06
影响因子：
11.1
作者：
Garavan, H;Ross, TJ;Stein, EA
通讯作者：
Stein, EA
影响因子：
16.2
作者：
Gold, BT;Buckner, RL
通讯作者：
Buckner, RL
影响因子：
2.4
作者：
Atkins, Alexandra S.;Reuter-Lorenz, Patricia A.
通讯作者：
Reuter-Lorenz, Patricia A.