Brief Post-Surgical Stress Management Reduces Pro-Inflammatory Cytokines in Overweight and Obese Breast Cancer Patients Undergoing Primary Treatment.
Brief Post-Surgical Stress Management Reduces Pro-Inflammatory Cytokines in Overweight and Obese Breast Cancer Patients Undergoing Primary Treatment.
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DOI：
10.31083/j.fbl2705148
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发表时间：
2022-05-07
影响因子：
3.1
通讯作者：
Antoni, Michael H.
中科院分区：
文献类型：
--
作者：
Ream, Molly;Saez-Clarke, Estefany;Taub, Chloe;Diaz, Alain;Frasca, Daniela;Blomberg, Bonnie B.;Antoni, Michael H.
超重和肥胖（OW/OB）的身体质量指数（BMI）与乳腺癌（BC）中更大的炎症和更差的结果相关。使用认知行为疗法（CBT）和放松训练（RT）的压力管理干预措施减少了BC患者的炎症，但尚未在接受初级治疗的OW/OB患者中进行专门测试。我们开发了简短的CBT和RT为基础的团体干预措施，并测试其对OW/OB与正常体重（NW）BC患者在主要治疗期间血清炎症细胞因子（IL-6，IL-1β和TNF-α）的影响（与时间匹配的健康教育[HE]对照）。我们假设OW/OB妇女会表现出更高水平的炎性细胞因子，压力管理会减少这些细胞因子在OW/OB妇女比在NW妇女。0 - III期BC患者在手术后和开始辅助治疗前入组，随机接受5周CBT、RT或HE，并在基线和6个月时提供问卷和血液样本。通过ELISA测量血清细胞因子水平。重复测量方差分析测试了BMI与时间的相互作用，以预测6个月内的细胞因子水平，控制年龄，阶段，种族和收入。样本（N = 153）大多数为OW/OB（55.6%）。我们发现不同BMI类别的基线IL-6和IL-1β存在差异，OW和OB女性的IL-6（p < 0.005）和IL-1β（p < 0.04）高于NW女性，但OW和OB女性之间无差异。BMI组间基线TNF-α无差异。BMI类别调节了6个月内短暂压力管理干预对IL-6变化的影响（p = 0.028）：CBT/RT与HE相比，OW/OB患者的IL-6降低（p = 0.045），但NW患者则没有（p = 0.664）。对IL-1β或TNF-α无影响。结果不能用接受辅助治疗、处方药或体力活动变化的差异来解释。新诊断BC的OW/OB妇女术后血清IL-6和IL-1β水平显著高于NW妇女。在OW/OB患者中，通过初级治疗进行简短的压力管理可能会减少已知伴随辅助治疗的炎症标志物的增加，从而促进更好的结局。NCT 02103387。
Overweight and obese (OW/OB) body mass index (BMI) is associated with greater inflammation and poorer outcomes in breast cancer (BC). Stress management interventions using cognitive behavioral therapy (CBT) and relaxation training (RT) have reduced inflammation in BC patients but have not been tested specifically in OW/OB patients undergoing primary treatment. We developed brief CBT and RT-based group interventions and tested their effects (vs time-matched Health Education [HE] control) on serum inflammatory cytokines (IL-6, IL-1β and TNF-α) in OW/OB vs normal weight (NW) BC patients during primary treatment. We hypothesized OW/OB women would show higher levels of inflammatory cytokines, and that stress management would decrease these cytokines more in OW/OB women than in NW women. Stage 0 – III BC patients were enrolled post-surgery and before initiating adjuvant therapy, were randomized to either 5 weeks of CBT, RT, or HE, and provided questionnaires and blood samples at baseline and 6-months. Serum cytokine levels were measured by ELISA. Repeated measures analysis of variance tested the interaction of condition by BMI by time in predicting cytokine levels over 6 months, controlling for age, stage, ethnicity, and income. The sample (N = 153) majority was OW/OB (55.6%). We found differences in baseline IL-6 and IL-1β across BMI categories, with greater IL-6 (p < 0.005) and IL-1β (p < 0.04) in OW and OB vs NW women, but no difference between OW and OB women. There were no differences in baseline TNF-α among BMI groups. BMI category moderated the effect of brief stress management interventions on IL-6 changes over 6-months (p = 0.028): CBT/RT vs HE decreased IL-6 in OW/OB (p = 0.045) but not in NW patients (p = 0.664). There were no effects on IL-1β or TNF-α. Results could not be explained by differences in receipt of adjuvant therapy, prescription medications, or changes in physical activity. OW/OB women with newly diagnosed BC had significantly greater serum IL-6 and IL-1β than NW women post-surgery. Brief stress management delivered with primary treatment among OW/OB patients may reduce the increases in inflammatory markers known to accompany adjuvant treatments and could thus promote better outcomes. NCT02103387.
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影响因子：
10.6
作者：
Antoni, Michael H.;Lutgendorf, Susan K.;Blomberg, Bonnie;Carver, Charles S.;Lechner, Suzanne;Diaz, Alain;Stagl, Jamie;Arevalo, Jesusa M. G.;Cole, Steven W.
通讯作者：
Cole, Steven W.
DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
3.3
作者：
Bouchard LC;Antoni MH;Blomberg BB;Stagl JM;Gudenkauf LM;Jutagir DR;Diaz A;Lechner S;Glück S;Derhagopian RP;Carver CS
通讯作者：
Carver CS
DOI：
10.1590/s1679-45082015ao3344
发表时间：
2015-07
期刊：
Einstein (Sao Paulo, Brazil)
影响因子：
--
作者：
Cormanique TF;Almeida LE;Rech CA;Rech D;Herrera AC;Panis C
通讯作者：
Panis C
影响因子：
168.9
作者：
Colleoni, M;Li, SG;Goldhirsch, A
通讯作者：
Goldhirsch, A