Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application.
Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application.
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DOI：
10.1155/2016/4209891
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发表时间：
2016
影响因子：
4.3
通讯作者：
About I
中科院分区：
文献类型：
--
作者：
Bakopoulou A;About I
牙齿间充质干细胞（MSCs），包括牙髓干细胞（DPSC），人类脱落乳牙干细胞（SHED）和根尖乳头干细胞（SCAP），已被广泛研究，使用高度复杂的体外和体内系统，大大提高了对其有趣的生物学特性的理解。它们重建各种牙齿和非牙齿组织的能力以及它们的分泌组固有的血管生成、神经生成和免疫调节特性在过去十年中一直是各种小组进行细致和昂贵研究的主题。关键的里程碑式成就已经证明了它们在再生牙科中的临床实用性，作为传统生物材料方法的替代治疗模块，提供受损口腔组织的再生，而不是简单地“填补空白”。因此，验证这些巨大进步的关键下一步是实施精心设计的临床试验，为利用这些迷人的研究成果为患者福祉铺平道路：这一突破性技术的最终目标。这篇综述文章简要概述了人类牙科间充质干细胞的主要生物学特性，关键的翻译途径“从实验室到临床。”
Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of their intriguing biological properties. Their capacity to reconstitute various dental and nondental tissues and the inherent angiogenic, neurogenic, and immunomodulatory properties of their secretome have been a subject of meticulous and costly research by various groups over the past decade. Key milestone achievements have exemplified their clinical utility in Regenerative Dentistry, as surrogate therapeutic modules for conventional biomaterial-based approaches, offering regeneration of damaged oral tissues instead of simply “filling the gaps.” Thus, the essential next step to validate these immense advances is the implementation of well-designed clinical trials paving the way for exploiting these fascinating research achievements for patient well-being: the ultimate aim of this ground breaking technology. This review paper presents a concise overview of the major biological properties of the human dental MSCs, critical for the translational pathway “from bench to clinic.”
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影响因子：
3.7
作者：
Bronckaers A;Hilkens P;Fanton Y;Struys T;Gervois P;Politis C;Martens W;Lambrichts I
通讯作者：
Lambrichts I
影响因子：
4.1
作者：
Akintoye, Sunday O.;Lam, Thanh;Robey, Pamela G.
通讯作者：
Robey, Pamela G.
影响因子：
4.1
作者：
Arnsdorf, Emily J.;Jones, Luis M.;Jacobs, Christopher R.
通讯作者：
Jacobs, Christopher R.
影响因子：
3.2
作者：
Chang, Chia-Chieh;Chang, Kai-Chun;Lin, Chun-Pin
通讯作者：
Lin, Chun-Pin
影响因子：
3.9
作者：
Abdullah, Muhammad Fawwaz;Abdullah, Siti Fadilah;Mokhtar, Khairani Idah
通讯作者：
Mokhtar, Khairani Idah