The association of prefrontal cortex response during a natural reward cue-reactivity paradigm, anhedonia, and demoralization in persons maintained on methadone.
The association of prefrontal cortex response during a natural reward cue-reactivity paradigm, anhedonia, and demoralization in persons maintained on methadone.
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美沙酮维持者在自然奖励线索反应范式、快感缺乏和道德败坏过程中前额叶皮层反应的关联。
DOI：
10.1016/j.addbeh.2020.106673
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发表时间：
2021-03
影响因子：
4.4
通讯作者：
Dunn KE
中科院分区：
文献类型：
--
作者：
Huhn AS;Brooner RK;Sweeney MM;Antoine D;Hammond AS;Ayaz H;Dunn KE
阿片类药物使用障碍（OUD）患者经常经历快感缺失和道德败坏，但对OUD治疗和康复过程中快感缺失和道德败坏的病理生理学研究相对较少。在目前的研究中，维持美沙酮的人（N=29）在功能性近红外光谱（fNIRS）成像过程中经历了自然奖励线索范式。自然奖励线索包括非常可口的食物，积极的社会互动（例如，一个幸福的家庭在餐桌上），和情感上的亲密（例如，夫妇拥抱或亲吻，但没有色情图像）。参与者还自我报告了Snaith-Hamilton快乐量表（SHPS）上的快感缺失症状和Demoralization Scale II（DS-II）上的士气低落症状。在SHPS上报告具有临床意义的快感缺失的参与者显示，响应自然奖励线索的右前额叶皮层（PFC）神经活动减少（F（1，25）=3.612，p=0.027，ηp2=0.302）。在积极社会线索的线性回归模型中，右侧VMPFC的神经活动减少与SHPS总分增加相关（F（1，27）=7.131，R2= 0.209，p= 0.013），右侧VMPFC和DLPFC区域的神经活动减少与DS-II总分增加相关（F（1，27）= 10.641，R2= 0.283，p=0.003。这项研究提供了初步的证据表明，前额叶皮层参与了从OUD恢复的人的快感缺乏和士气低落的病理生理学。快感缺失和士气低落是重要的治疗结果，应与一系列身心健康结果一起沿着查询，以评估美沙酮维持和其他OUD治疗方式需要改进的领域。
Persons with opioid use disorder (OUD) often experience anhedonia and demoralization, yet there is relatively little research on the pathophysiology of anhedonia and demoralization in OUD treatment and recovery. In the current study, persons maintained on methadone (N=29) underwent a natural reward-cue paradigm during functional near-infrared spectroscopy (fNIRS) imaging. Natural reward cues included highly palatable food, positive social interactions (e.g., a happy family at the dinner table), and emotional intimacy (e.g. couples embracing or kissing, but no erotic images). Participants also self-reported symptoms of anhedonia on the Snaith-Hamilton Pleasure Scale (SHPS) and demoralization on the Demoralization Scale II (DS-II). Participants who reported clinically-significant anhedonia on the SHPS displayed decreased neural activity in the right prefrontal cortex (PFC) in response to natural reward cues (F(1,25)=3.612, p=0.027, ηp2=0.302). In linear regression models of positive social cues, decreased neural activity in the right VMPFC was associated with increased SHPS total score (F(1,27)=7.131, R2=.209, p=.013), and decreased neural activity in an area encompassing the right lateral VMPFC and DLPFC was associated with increased DS-II total score (F(1,27) = 10.641, R2=.283, p=0.003. This study provides initial evidence that the prefrontal cortex is involved in the pathophysiology of anhedonia and demoralization in persons in recovery from OUD. Anhedonia and demoralization are important treatment outcomes that should be queried along with a constellation of physical and mental health outcomes, to assess areas of needed improvement in methadone maintenance and other OUD treatment modalities.
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影响因子：
15.9
作者：
Der-Avakian A;Markou A
通讯作者：
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影响因子：
7.6
作者：
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De Risio, S