Body size and breast cancer in a black population--the Barbados National Cancer Study.
Body size and breast cancer in a black population--the Barbados National Cancer Study.
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DOI：
10.1007/s10552-008-9253-3
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发表时间：
2009-04
影响因子：
2.3
通讯作者：
Leske, M. Cristina
中科院分区：
文献类型：
--
作者：
Nemesure, Barbara;Wu, Suh-Yuh;Hennis, Anselm;Leske, M. Cristina
评估非洲裔加勒比人群中体型与乳腺癌发病率之间的关系。这项研究是基于巴巴多斯国家癌症研究（BNCS）的222例乳腺癌病例和454例对照组，其中包括身高，体重，体重指数（BMI），腰围和臀围（WC，HC）和腰臀比（WHR）的身体尺寸变量进行了比较。进行了多变量调整的logistic回归分析，结果以比值比（OR）和95%置信区间（CI）表示。尽管33%的病例和39%的对照者肥胖（BMI ≥ 30 kg/m2），但在多变量分析中未发现BMI是乳腺癌的显著预测因素。身高增加≥50岁女性的风险（OR = 2.16，95% CI（1.02，4.58）），WC和WHR均显示出年龄的双重效应（年龄≤50岁的风险降低;年龄≥50岁的风险增加）。在非洲裔人群中，体型似乎影响乳腺癌的风险。BNCS的数据表明，一些但不是所有的体型因素在乳腺癌风险中起作用，年龄可能会影响这些关系。
To evaluate the relationship between body size and incident breast cancer in an African-origin Caribbean population. This investigation is based on 222 incident breast cancer cases and 454 controls from the Barbados National Cancer Study (BNCS) in whom body size variables that included height, weight, body-mass index (BMI), waist and hip circumferences (WC, HC), and waist–hip ratio (WHR) were compared. Multivariate-adjusted logistic regression analyses were performed and the findings are presented as odds ratios (ORs) with 95% confidence intervals (CI). Although 33% of cases and 39% of controls were obese (BMI ≥ 30 kg/m2), BMI was not found to be a significant predictor of breast cancer in the multivariate analyses. Tall stature increased risk among women ≥50 years (OR = 2.16, 95% CI (1.02, 4.58)), and a dual effect with age was suggested for both WC and WHR (decreased risk for those aged ≤50 years; increased risk among those ≥50 years). Body size appears to influence the risk of breast cancer in this population of African origin. The BNCS data suggest that a few, but not all body size factors play a role in breast cancer risk, and that age may affect these relationships.
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影响因子：
7.4
作者：
Adebamowo, CA;Ogundiran, TO;Adenipekun, AA;Oyesegun, RA;Campbell, OB;Akang, EE;Rotimi, CN;Olopade, OI
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影响因子：
8.4
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通讯作者：
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影响因子：
5
作者：
COWAN, LD;GORDIS, L;JONES, GS
通讯作者：
JONES, GS