Depressive symptoms and adipokines in women: Study of women's health across the nation.
Depressive symptoms and adipokines in women: Study of women's health across the nation.
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DOI：
10.1016/j.psyneuen.2018.07.011
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发表时间：
2018-11
影响因子：
3.7
通讯作者：
Bromberger JT
中科院分区：
文献类型：
--
作者：
Everson-Rose SA;Clark CJ;Wang Q;Guo H;Mancuso P;Kravitz HM;Bromberger JT
小型临床研究表明，抑郁症与脂联素和瘦素的改变有关，脂联素和瘦素是脂肪细胞衍生的分泌蛋白，参与代谢调节。然而，缺乏这些关联的纵向数据。本研究检查了健康中年女性（平均（SD）年龄，45.6（2.5）岁）抑郁症状和重度抑郁症（MDD）与脂联素和瘦素的横断面和纵向关联。横断面分析包括 575 名具有基线脂肪因子数据的女性；纵向分析包括 262 名女性，在 5 年内进行了 2-4 次脂肪因子测量。流行病学研究中心抑郁量表（CES-D）的20项用于评估抑郁症状； MDD 病史通过 DSM-IV 的结构化临床访谈确定。从储存的血清样本中测定脂肪因子；对数值进行对数转换以进行分析。线性和重复测量随机效应回归模型分别评估了基线 CES-D 评分与基线脂肪因子浓度和随时间变化的关联。二次分析评估了 MDD 病史与脂肪因子浓度的关系。脂联素和瘦素的平均 (SD) 基线浓度分别为 9.90 (4.92) μg/mL 和 27.02 (20.06) ng/mL；两者都随着时间的推移而增加 (p<.0001)。 CES-D 评分与基线时（每 1-SD：估计=−0.04，SE=.02，p=.03）和随时间推移（每 1-SD：估计=−0.055，SE=.024，p=.02）较低的脂联素相关。风险因素调整模型中的关联性没有变化。与 CES-D < 16 的女性相比，CES-D 评分较高 (≥16) 的女性基线时脂联素中位数较低 6.9% (95% CI: -1.1%, 14.3%; p=.089)，并且在调整模型中随着时间的推移，中位脂联素较低 11.5% (95% CI: 1.5%, 20.4%, p=.025)。脂肪因子的变化率不因基线抑郁症状或重度抑郁症病史而变化。抑郁症状和MDD病史与瘦素无关。在中年女性中，抑郁症状与脂联素降低有关，脂联素是一种与代谢和心血管疾病有关的重要抗炎生物标志物。
Small clinical studies suggest depression is associated with alterations in adiponectin and leptin, adipocyte-derived secretory proteins involved in metabolic regulation; however, longitudinal data on these association are lacking. This study examined cross-sectional and longitudinal associations of depressive symptoms and major depressive disorder (MDD) with adiponectin and leptin in healthy middle-aged women (mean (SD) age, 45.6 (2.5) years). Cross-sectional analyses included 575 women with baseline adipokine data; longitudinal analyses included 262 women with 2–4 adipokine measurements over 5 years. The 20-item Center for Epidemiologic Studies Depression scale (CES-D) was used to assess depressive symptoms; history of MDD was determined by the Structured Clinical Interview for DSM-IV. Adipokines were assayed from stored serum specimens; values were log-transformed for analyses. Linear and repeated measure random effects regression models evaluated associations of baseline CES-D scores with baseline adipokine concentrations and changes over time, respectively. Secondary analyses evaluated the relation of MDD history with adipokine concentrations. Mean (SD) baseline concentrations of adiponectin and leptin were 9.90 (4.92) μg/mL and 27.02 (20.06) ng/mL; both increased over time (p<.0001). CES-D scores were associated with lower adiponectin at baseline (per 1-SD: estimate=−0.04, SE=.02, p=.03) and over time (per 1-SD: estimate=−0.055, SE=.024, p=.02). Associations were unchanged in risk factor-adjusted models. Women with elevated CES-D scores (≥16) had 6.9% (95% CI: −1.1%, 14.3%; p=.089) lower median adiponectin at baseline and 11.5% (95% CI: 1.5%, 20.4%, p=.025) lower median adiponectin over time in adjusted models, compared to women with CES-D<16. Rate of change in adipokines did not vary by baseline depressive symptoms or MDD history. Depressive symptoms and MDD history were unrelated to leptin. In women at midlife, depressive symptoms are associated with lower adiponectin, a critical anti-inflammatory biomarker involved in metabolic and cardiovascular conditions.
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影响因子：
1.8
作者：
Hasan-Ali, Hosam;El-Mottaleb, Nashwa A. Abd;Abd-Elsayed, Alaa
通讯作者：
Abd-Elsayed, Alaa
影响因子：
5.3
作者：
Beatty AL;Zhang MH;Ku IA;Na B;Schiller NB;Whooley MA
通讯作者：
Whooley MA
影响因子：
4.9
作者：
Ciccone, M;Vettor, R;De Pergola, G
通讯作者：
De Pergola, G
影响因子：
8.9
作者：
Lihn, AS;Pedersen, SB;Richelsen, B
通讯作者：
Richelsen, B
影响因子：
4.8
作者：
Diniz, Breno S.;Teixeira, Antonio L.;Forlenza, Orestes V.
通讯作者：
Forlenza, Orestes V.