Striatal and extrastriatal dopamine release measured with PET and [(18)F] fallypride.
Striatal and extrastriatal dopamine release measured with PET and [(18)F] fallypride.
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DOI：
10.1002/syn.20734
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发表时间：
2010-05
期刊：
影响因子：
2.3
通讯作者：
Abi-Dargham, Anissa
中科院分区：
文献类型：
--
作者：
Slifstein, Mark;Kegeles, Lawrence S.;Xu, Xiaoyan;Thompson, Judy L.;Urban, Nina;Castrillon, John;Hackett, Elizabeth;Bae, S. -A.;Laruelle, Marc;Abi-Dargham, Anissa
安非他明激发法，将安非他明给药后的PET或SPECT放射配体结合与基线值进行比较，已成功地用于许多脑成像研究，作为多巴胺能功能的指标，特别是在纹状体中。[18F] fallypride是首个PET放射配体，可以在服用安非他明后的单次扫描中测量安非他明对纹状体和纹状体外脑区D2/D3配体结合的影响。我们使用基于动脉血浆输入的建模和参考区域方法，在基线和服用安非他明（0.3 mg/kg）时扫描了15名健康志愿者[18F]。我们发现安非他明效应在腹侧纹状体、白球和后壳核中被强烈检测到，在其他纹状体亚区具有稍高的变异性。然而，在纹状体中观察到的效应量小于我们实验室先前使用[11C] raclopride进行的研究。在边缘纹状体外区（海马、杏仁核）和黑质也检测到强有力的效果，但在皮质区域的信噪比太低，无法准确测量。我们认为[18F] fallypride是测量纹状体和边缘区域安非他明效应的合适配体，但不适合测量皮质区域的效应，可能不是测量纹状体效应的最有力方法。
The amphetamine challenge, in which PET or SPECT radioligand binding following administration of amphetamine is compared to baseline values, has been successfully used in a number of brain imaging studies as an indicator of dopaminergic function, particularly in the striatum. [18F] fallypride is the first PET radioligand that allows measurement of the effects of amphetamine on D2/D3 ligand binding in striatum and extra-striatal brain regions in a single scanning session following amphetamine. We scanned 15 healthy volunteer subjects with [18F] fallypride at baseline and following amphetamine (0.3 mg/kg) using arterial plasma input based modeling as well as reference region methods. We found that amphetamine effect was robustly detected in ventral striatum, globus pallidus and posterior putamen, and with slightly higher variability in other striatal subregions. However, the observed effect sizes in striatum were less than those observed in previous studies in our lab using [11C] raclopride. Robust effect was also detected in limbic extra-striatal regions (hippocampus, amygdala) and substantia nigra, but the signal to noise ratio was too low to allow accurate measurement in cortical regions. We conclude that [18F] fallypride is a suitable ligand for measuring amphetamine effect in striatum and limbic regions, but is not suitable for measuring the effect in cortical regions and may not provide the most powerful way to measure the effect in striatum.
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