White-Matter Repair as a Novel Therapeutic Target for Early Adversity.
White-Matter Repair as a Novel Therapeutic Target for Early Adversity.
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DOI：
10.3389/fnins.2021.657693
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发表时间：
2021
影响因子：
4.3
通讯作者：
Kaffman A
中科院分区：
文献类型：
--
作者：
Islam R;Kaffman A
早期逆境（EA）损害髓鞘发育的方式，持续在以后的生活在不同的哺乳动物物种，包括人类，非人灵长类动物和啮齿动物。这些观察结果，再加上髓鞘发育的高度保守性，表明动物模型可以提供重要的见解的分子机制，EA损害髓鞘发育以后的生活和这些变化对网络连接，认知和行为的影响。然而，这一领域的翻译研究得到了相对较少的关注，目前没有全面的审查，以解决这些问题。鉴于最近在啮齿动物中进行的一些机制研究以及增加髓鞘形成的新药物的可用性，这一点尤为重要。本次审查的目标是强调需要在这一领域的额外的临床前工作，并提供具体的例子，证明这项工作的潜力，以产生新的治疗干预措施，是非常需要的。
Early adversity (EA) impairs myelin development in a manner that persists later in life across diverse mammalian species including humans, non-human primates, and rodents. These observations, coupled with the highly conserved nature of myelin development suggest that animal models can provide important insights into the molecular mechanisms by which EA impairs myelin development later in life and the impact of these changes on network connectivity, cognition, and behavior. However, this area of translational research has received relatively little attention and no comprehensive review is currently available to address these issues. This is particularly important given some recent mechanistic studies in rodents and the availability of new agents to increase myelination. The goals of this review are to highlight the need for additional pre-clinical work in this area and to provide specific examples that demonstrate the potential of this work to generate novel therapeutic interventions that are highly needed.
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DOI：
10.1177/1073858416667720
发表时间：
2017-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bassett DS;Bullmore ET
通讯作者：
Bullmore ET
影响因子：
26.1
作者：
Bick, Johanna;Zhu, Tong;Stamoulis, Catherine;Fox, Nathan A.;Zeanah, Charles;Nelson, Charles A.
通讯作者：
Nelson, Charles A.
影响因子：
3.1
作者：
Duque, Alvaro;Coman, Daniel;Simen, Arthur A.
通讯作者：
Simen, Arthur A.
影响因子：
10.6
作者：
De Bellis, MD;Keshavan, MS;Ryan, ND
通讯作者：
Ryan, ND
影响因子：
2.2
作者：
Coe, CL;Lulbach, GR;Schneider, ML
通讯作者：
Schneider, ML