Altered default network activity in obesity.
Altered default network activity in obesity.
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DOI：
10.1038/oby.2011.119
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Cornier MA
中科院分区：
文献类型：
--
作者：
Tregellas JR;Wylie KP;Rojas DC;Tanabe J;Martin J;Kronberg E;Cordes D;Cornier MA
能量摄入的调节是一个复杂的过程，涉及稳态信号和内部和外部感觉输入的整合。为了更好地理解这一过程的神经生物学以及它在肥胖症中可能是如何功能失调的，这项研究检查了与瘦个体相比，肥胖减轻者（RO）大脑“默认网络”的活动。默认网络是一组功能连接的大脑区域，被认为在内部定向认知活动以及外部和内部感觉处理之间的相互作用中发挥重要作用。功能性磁共振成像进行了24瘦和18 RO个人在禁食状态后2天的能量摄入和2天后的30%的过度喂养的平衡设计。扫描进行，而受试者被动地观看食物和非食物物体的图像。使用独立分量分析来识别默认网络组件。在eucaloric状态下，更大的默认网络活动，观察RO相比，在外侧下顶叶和后扣带皮层瘦的个人。活动与食欲呈正相关。过度喂养导致默认网络活动增加瘦，但不是RO个人。这些研究结果表明，默认网络的功能，内在神经元活动的主要贡献者，在肥胖和/或肥胖倾向的个人改变。未来对该网络功能及其与其他大脑网络关系的研究可能会提高我们对肥胖机制和治疗的理解。
The regulation of energy intake is a complex process involving the integration of homeostatic signals and both internal and external sensory inputs. To better understand the neurobiology of this process and how it may be dysfunctional in obesity, this study examined activity of the brain’s “default network” in reduced-obese (RO) as compared to lean individuals. The default network is a group of functionally connected brain regions thought to play an important role in internally directed cognitive activity and the interplay between external and internal sensory processing. Functional magnetic resonance imaging was performed in 24 lean and 18 RO individuals in the fasted state after 2 days of eucaloric energy intake and after 2 days of 30% overfeeding in a counterbalanced design. Scanning was performed while subjects passively viewed images of food and nonfood objects. Independent component analysis was used to identify the default network component. In the eucaloric state, greater default network activity was observed in RO compared to lean individuals in the lateral inferior parietal and posterior cingulate cortices. Activity was positively correlated with appetite. Overfeeding resulted in increased default network activity in lean but not RO individuals. These findings suggest that the function of the default network, a major contributor to intrinsic neuronal activity, is altered in obesity and/or obese-prone individuals. Future studies of the network’s function and its relationship to other brain networks may improve our understanding of the mechanisms and treatment of obesity.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
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影响因子：
7.1
作者：
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影响因子：
5.7
作者：
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影响因子：
5.7
作者：
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通讯作者：
Marrelec, Guillaume
影响因子：
3.2
作者：
Greicius, MD;Menon, V
通讯作者：
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