Aryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation.
Aryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation.
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DOI：
10.1007/s00281-013-0393-5
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发表时间：
2013-11
影响因子：
9
通讯作者：
Zhou, Liang
中科院分区：
文献类型：
--
作者：
Qiu, Ju;Zhou, Liang
与感染期间需要抗原识别和功能成熟的适应性免疫细胞不同，先天淋巴样细胞（ILC）通常对病原体迅速作出反应，并作为感染性疾病的第一道防线。RAR相关孤儿受体（RORγt）+ILC是近年来研究较多的先天性细胞群之一。在胎儿发育阶段，RORγt+ ILC（例如，淋巴组织诱导物-LTi细胞）是淋巴器官发生所必需的。在成年小鼠中，RORγt+ ILC大量存在于肠道中以发挥免疫防御功能。然而，在某些情况下，RORγt+ ILC可能是致病性的，并有助于肠道炎症。芳烃受体（Aryl hydrocarbon receptor，Ahr）是一种配体依赖性转录因子，广泛表达于多种免疫和非免疫细胞。在肠道中，Ahr的配体可以来源于/产生自饮食、微生物区系和/或宿主细胞。已显示Ahr调节免疫系统中的不同细胞群体，包括RORγt+ ILC、T辅助（Th）17/22细胞、γδT细胞、调节性T细胞（TcR）、Tr 1细胞和抗原呈递细胞（APC）。本文就RORγt+ ILC的发育和功能，以及Ahr在小鼠和人类肠道免疫和炎症中的作用作一综述。更好地了解Ahr在肠道中的功能对于开发新的治疗手段以在未来治疗感染性和自身免疫性疾病中靶向Ahr是重要的。
Unlike adaptive immune cells that require antigen recognition and functional maturation during infection, innate lymphoid cells (ILCs) usually respond to pathogens promptly and serve as the first line of defense in infectious diseases. RAR-related orphan receptors (RORγt)+ ILCs are one of the innate cell populations that have recently been intensively studied. During the fetal stage of development, RORγt+ ILCs (e.g., lymphoid tissue inducer-LTi cells) are required for lymphoid organogenesis. In adult mice, RORγt+ ILCs are abundantly present in the gut to exert immune defensive functions. Under certain circumstances, however, RORγt+ ILCs can be pathogenic and contribute to intestinal inflammation. Aryl hydrocarbon receptor (Ahr), a ligand-dependent transcriptional factor, is widely expressed by various immune and non-immune cells. In the gut, the ligand for Ahr can be derived/generated from diet, microflora, and/or host cells. Ahr has been shown to regulate different cell populations in the immune system including RORγt+ ILCs, T helper (Th)17/22 cells, γδT cells, regulatory T cells (Tregs), Tr1 cells, and antigen presenting cells (APCs). In this review, we will focus on the development and function of RORγt+ ILCs, and discuss the role of Ahr in intestinal immunity and inflammation in mice and in humans. Better understanding the function of Ahr in the gut is important for developing new therapeutic means to target Ahr in future treatment of infectious and autoimmune diseases.
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影响因子：
30.5
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影响因子：
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