Versatile Types of Polysaccharide-Based Drug Delivery Systems: From Strategic Design to Cancer Therapy.
Versatile Types of Polysaccharide-Based Drug Delivery Systems: From Strategic Design to Cancer Therapy.
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多种类型的多糖药物输送系统：从战略设计到癌症治疗
DOI：
10.3390/ijms21239159
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发表时间：
2020-12-01
影响因子：
5.6
通讯作者：
Hu H
中科院分区：
文献类型：
--
作者：
Sun Y;Jing X;Ma X;Feng Y;Hu H
化疗仍然是目前最直接、最有效的癌症治疗手段。药物传递系统（dds）的提出有效地改善了传统化疗药物的许多缺点。dds的技术支撑在于其优异的材料性能。多糖包括一系列天然聚合物，如壳聚糖、透明质酸和海藻酸。这些多糖具有良好的生物相容性和可降解性，并且易于化学修饰。因此，多糖是构建dss的理想候选材料，其临床应用前景受到研究人员的青睐。在多糖种类繁多的基础上，综述了多糖从策略设计到癌症治疗的应用。重点阐述了多糖基dss的构建和修饰方法，并对多糖基dss在肿瘤治疗中的最新研究进展进行了综述。本文综述的目的是为设计和制备性能优良的多糖基dds提供参考。
Chemotherapy is still the most direct and effective means of cancer therapy nowadays. The proposal of drug delivery systems (DDSs) has effectively improved many shortcomings of traditional chemotherapy drugs. The technical support of DDSs lies in their excellent material properties. Polysaccharides include a series of natural polymers, such as chitosan, hyaluronic acid, and alginic acid. These polysaccharides have good biocompatibility and degradability, and they are easily chemical modified. Therefore, polysaccharides are ideal candidate materials to construct DDSs, and their clinical application prospects have been favored by researchers. On the basis of versatile types of polysaccharides, this review elaborates their applications from strategic design to cancer therapy. The construction and modification methods of polysaccharide-based DDSs are specifically explained, and the latest research progress of polysaccharide-based DDSs in cancer therapy are also summarized. The purpose of this review is to provide a reference for the design and preparation of polysaccharide-based DDSs with excellent performance.
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影响因子：
9.5
作者：
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通讯作者：
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DOI：
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