Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure.
Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure.
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DOI：
10.1371/journal.pone.0005916
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发表时间：
2009-06-16
期刊：
影响因子：
3.7
通讯作者：
Hoover EA
中科院分区：
文献类型：
--
作者：
Mathiason CK;Hays SA;Powers J;Hayes-Klug J;Langenberg J;Dahmes SJ;Osborn DA;Miller KV;Warren RJ;Mason GL;Hoover EA
了解朊病毒疾病（包括鹿的慢性消耗性疾病（CWD））的流行病学和发病机制的关键是确定从一个个体到另一个个体的传播方式。我们之前曾报道过，感染 CWD 的鹿的唾液和血液中含有足够的传染性朊病毒，可在进入幼鹿体内时传播疾病。在这里，我们再次对鹿进行生物测定，结果表明，出现症状前的鹿的血液和唾液中含有能够感染未接触过的鹿的传染性朊病毒，并且仅接触来自 CWD 感染鹿组的环境污染物的未接触过的鹿在初次接触后 15 个月后获得了 CWD 感染。这些结果有助于进一步解释 CWD 容易传播的基础，强调自然环境中与 CWD 在鹿科动物之间传播相关的复杂性，强调基于血液的检测在检测临床前 CWD 感染方面的潜在效用，并可能预示其他朊病毒感染中的类似传播动态。
Key to understanding the epidemiology and pathogenesis of prion diseases, including chronic wasting disease (CWD) of cervids, is determining the mode of transmission from one individual to another. We have previously reported that saliva and blood from CWD-infected deer contain sufficient infectious prions to transmit disease upon passage into naïve deer. Here we again use bioassays in deer to show that blood and saliva of pre-symptomatic deer contain infectious prions capable of infecting naïve deer and that naïve deer exposed only to environmental fomites from the suites of CWD-infected deer acquired CWD infection after a period of 15 months post initial exposure. These results help to further explain the basis for the facile transmission of CWD, highlight the complexities associated with CWD transmission among cervids in their natural environment, emphasize the potential utility of blood-based testing to detect pre-clinical CWD infection, and could augur similar transmission dynamics in other prion infections.
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影响因子：
3.5
作者：
Gonzalez-Romero, Dennisse;Barria, Marcelo A.;Leon, Patricia;Morales, Rodrigo;Soto, Claudio
通讯作者：
Soto, Claudio
DOI：
10.1186/1476-069x-7-31
发表时间：
2008-06-24
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Garruto RM;Reiber C;Alfonso MP;Gastrich H;Needham K;Sunderman S;Walker S;Weeks J;Derosa N;Faisst E;Dunn J;Fanelli K;Shilkret K
通讯作者：
Shilkret K
影响因子：
--
作者：
Anderson, C. Alan;Bosque, Patrick;Tyler, Kenneth L.
通讯作者：
Tyler, Kenneth L.
影响因子：
168.9
作者：
Houston, F;Foster, JD;Bostock, CJ
通讯作者：
Bostock, CJ
影响因子：
168.9
作者：
Llewelyn, CA;Hewitt, PE;Will, RG
通讯作者：
Will, RG