Endogenous secretory receptor for advanced glycation end products is associated with low serum interleukin-1 receptor antagonist and elevated IL-6 in older community-dwelling adults.
Endogenous secretory receptor for advanced glycation end products is associated with low serum interleukin-1 receptor antagonist and elevated IL-6 in older community-dwelling adults.
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晚期糖基化终产物的内源性分泌受体与社区老年人中血清白细胞介素 1 受体拮抗剂的低水平和 IL-6 的升高有关。
DOI：
10.1093/gerona/glq225
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Ferrucci,Luigi
中科院分区：
文献类型：
--
作者：
Crasto,CandaceL;Semba,RichardD;Sun,Kai;Dalal,Mansi;Corsi,AnnaMaria;Bandinelli,Stefania;Guralnik,JackM;Ferrucci,Luigi
BackgroundAdvanced glycation end products (AGEs) are thought to cause inflammation through interaction with the receptor for AGEs (RAGE), therefore contributing to adverse aging-related processes. The relationship between AGEs, RAGE, and inflammation has not been well characterized.MethodsWe examined the relationship of plasma endogenous secretory RAGE (esRAGE); carboxymethyl-lysine (CML), a circulating AGE; and inflammatory mediators in 1,298 adults, 20–97 years, who participated in the InCHIANTI study in Tuscany, Italy. Blood levels of esRAGE, CML, interleukin-1 receptor antagonist (IL-1RA), IL-1β, tumor necrosis factor-α (TNF-α), IL-6, IL-6 receptor (IL-6R), IL-18, C-reactive protein (CRP), transforming growth factor-β (TGF-β), and fibrinogen were measured.ResultsLog plasma esRAGE was associated with log IL-1RA (β = −0.069,SE= 0.036,p= .05) and log IL-6 (β = 0.077,SE= 0.035,p= .03), respectively, in separate multivariable linear regression models, adjusting for potential confounders. Log plasma esRAGE was also negatively associated with log TGF-β but did not reach statistical significance (β = −0.091,SE= 0.053,p= .09). Log plasma esRAGE was not significantly associated with log IL-1β, log TNF-α, IL-6R, log IL-18, or CRP. Log plasma CML was not associated with any of the inflammatory mediators except for IL-6R (β = −14.10,SE= 5.94,p= .02) and fibrinogen (β = 13.95,SE= 7.21,p= .05) in separate multivariable models, adjusting for potential confounders.ConclusionsPlasma esRAGE is correlated with higher IL-6 and lower IL-1RA. These findings suggest that plasma esRAGE plays a role in modulating inflammation, although the exact mechanisms remain to be elucidated.
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影响因子：
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DOI：
--
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