Intraepithelial Macrophage Expressing CD163 Is a Histopathological Clue to Evaluate the Malignant Potency of Oral Lichenoid Condition: A Case Report and Immunohistochemical Investigation.
Intraepithelial Macrophage Expressing CD163 Is a Histopathological Clue to Evaluate the Malignant Potency of Oral Lichenoid Condition: A Case Report and Immunohistochemical Investigation.
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DOI：
10.3390/diagnostics10090624
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发表时间：
2020-08-23
期刊：
影响因子：
--
通讯作者：
Yokozaki H
中科院分区：
文献类型：
--
作者：
Shigeoka M;Koma YI;Kanzawa M;Akashi M;Yokozaki H
口腔苔藓样变(OLC)包括口腔扁平苔藓(OLP)、口腔苔藓样病变和口腔苔藓样异型增生，其发病机制和生物学恶性程度各不相同。然而，根据临床或组织学特征区分它们是困难的。众所周知，CD163+巨噬细胞与口腔癌的侵袭性有关。我们最近证实非癌病变的CD163+巨噬细胞渗入间质，而不是上皮内区域。在这份报告中，我们描述了一个OLC的病例，通过第一次局部活检没有检测到恶性。此外，我们通过回顾比较以CD163+巨噬细胞为重点的局部活检和切除标本的组织学结果来评估OLC的恶性潜能。1例72岁男性，单侧颊粘膜白色病变，经活检确诊为口腔扁平苔藓，两年后发现浸润性癌。切除标本和活检标本上皮内CD163+巨噬细胞均可见。这是第一个证明上皮内CD163+巨噬细胞可能是识别OLC恶性潜能的值得注意的指标的报告。
Oral lichenoid conditions (OLC), including oral lichen planus (OLP), oral lichenoid lesions and oral lichenoid dysplasia, differ in pathogenesis and biological malignancy. However, distinguishing them based on clinical or histological features is difficult. It is well known that CD163+ macrophages are associated with oral cancer aggressiveness. We recently demonstrated that CD163+ macrophages of noncancerous lesions infiltrate the stroma, not the intraepithelial area. In this report, we describe a case of OLC that was not detected as malignant by the first local biopsy. Furthermore, we evaluated the malignant potency of OLC by retrospectively comparing the histological findings between local biopsy and resected specimens focusing on CD163+ macrophages. A 72-year-old man with a white lesion in the unilateral buccal mucosa was diagnosed with OLP through the biopsy although invasive cancer was detected two years later. Intraepithelial CD163+ macrophages were found not only on the resected specimen but also biopsy. This is the first report to demonstrate that intraepithelial CD163+ macrophages may be noteworthy indicators to identify the malignant potency of OLC.
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DOI：
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发表时间：
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期刊：
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