CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma.
CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma.
复制标题
DOI：
10.1155/2014/838632
复制
发表时间：
2014
影响因子：
--
通讯作者：
Sun ZJ
中科院分区：
文献类型：
--
作者：
He KF;Zhang L;Huang CF;Ma SR;Wang YF;Wang WM;Zhao ZL;Liu B;Zhao YF;Zhang WF;Sun ZJ
肿瘤相关巨噬细胞（TAM）在多种癌症的进展和预后中发挥着重要作用。然而，TAM标志物在口腔鳞状细胞癌（OSCC）中的作用和临床意义尚未阐明。本研究旨在通过组织微阵列研究TAM标记物的表达与OSCC病理特征之间的相关性。通过免疫组织化学研究了包含 16 例正常口腔粘膜、6 例口腔上皮发育不良和 43 例 OSCC 标本的组织微阵列。我们观察到从正常口腔粘膜到OSCC，TAM标记物CD68和CD163以及癌症干细胞（CSC）标记物ALDH1、CD44和SOX2的蛋白表达依次增加。 CD68和CD163的表达与淋巴结状态显着相关，SOX2与病理分级和淋巴结状态显着相关，而ALDH1与肿瘤分期相关。此外，CD68 与 CD163、SOX2 和 ALDH1 显着相关（P < 0.05）。 Kaplan-Meier分析显示，过度表达CD163的OSCC患者的总生存率显着较差（P < 0.05）。 TAM 标记物与癌症干细胞标记物和 OSCC 总生存率相关，表明它们在 OSCC 中具有潜在的预后价值。
Tumor-associated macrophages (TAMs) play an important role in the progression and prognostication of numerous cancers. However, the role and clinical significance of TAM markers in oral squamous cell carcinoma (OSCC) has not been elucidated. The present study was designed to investigate the correlation between the expression of TAM markers and pathological features in OSCC by tissue microarray. Tissue microarrays containing 16 normal oral mucosa, 6 oral epithelial dysplasia, and 43 OSCC specimens were studied by immunohistochemistry. We observed that the protein expression of the TAM markers CD68 and CD163 as well as the cancer stem cell (CSC) markers ALDH1, CD44, and SOX2 increased successively from the normal oral mucosa to OSCC. The expressions of CD68 and CD163 were significantly associated with lymph node status, and SOX2 was significantly correlated with pathological grade and lymph node status, whereas ALDH1 was correlated with tumor stage. Furthermore, CD68 was significantly correlated with CD163, SOX2, and ALDH1 (P < 0.05). Kaplan-Meier analysis revealed that OSCC patients overexpressing CD163 had significantly worse overall survival (P < 0.05). TAM markers are associated with cancer stem cell marker and OSCC overall survival, suggesting their potential prognostic value in OSCC.
登录
查看更多内容
影响因子：
3.7
作者：
Kong LQ;Zhu XD;Xu HX;Zhang JB;Lu L;Wang WQ;Zhang QB;Wu WZ;Wang L;Fan J;Tang ZY;Sun HC
通讯作者：
Sun HC
Keap1和Nrf2在口腔鳞状细胞癌中的临床意义
影响因子：
3.7
作者：
Huang CF;Zhang L;Ma SR;Zhao ZL;Wang WM;He KF;Zhao YF;Zhang WF;Liu B;Sun ZJ
通讯作者：
Sun ZJ
影响因子：
6.4
作者：
Maniecki, Maciej Bogdan;Etzerodt, Anders;Moller, Holger Jon
通讯作者：
Moller, Holger Jon
影响因子：
23.9
作者：
Lathia, Justin D.;Heddleston, John M.;Venere, Monica;Rich, Jeremy N.
通讯作者：
Rich, Jeremy N.
DOI：
10.1038/nri3070
发表时间：
2011-10-10
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--