The genetics of early telencephalon patterning: some assembly required.

The genetics of early telencephalon patterning: some assembly required.
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DOI:
10.1038/nrn2463
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发表时间:
2008-09
期刊:
Nature reviews. Neuroscience
影响因子:
--
通讯作者:
Fishell G
Fishell G
中科院分区:
其他
文献类型:
--
作者:
Hébert JM;Fishell G

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人类行为的巨大范围植根于大脑复杂的神经网络。这些网络的建立依赖于端脑不同区域中特定神经元亚型的精确整合。在这里,我们以小鼠为模型系统,回顾了这些增殖区是如何建立的。此外,我们讨论了这些地区如何可以追溯到一些关键基因的功能,包括那些编码成纤维细胞生长因子(FGF),音刺猬(SHH),骨形态发生蛋白(BMP),叉头框G1(FoxG1),配对框6(PAX6)和LIM同源框蛋白2(LHX 2),模式的早期端脑。
The immense range of human behaviours is rooted in the complex neural networks of the cerebrum. The creation of these networks depends on the precise integration of specific neuronal subtypes that are born in different regions of the telencephalon. Here, using the mouse as a model system, we review how these proliferative zones are established. Moreover, we discuss how these regions can be traced back in development to the function of a few key genes, including those that encode fibroblast growth factors (FGFs), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), forkhead box G1 (FoxG1), paired box 6 (PAX6) and LIM homeobox protein 2 (LHX2), that pattern the early telencephalon.
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