Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort.
Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort.
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DOI：
10.1002/ana.22055
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发表时间：
2010-08
影响因子：
11.2
通讯作者：
OBrien, Richard J.
中科院分区：
文献类型：
--
作者：
Dolan, Hillary;Crain, Barbara;Troncoso, Juan;Resnick, Susan M.;Zonderman, Alan B.;OBrien, Richard J.
虽然现在公认无症状性脑梗死是老年痴呆的重要原因，但动脉粥样硬化本身与痴呆之间的关系仍有争议。具体而言，目前尚不清楚动脉粥样硬化是否会导致定义阿尔茨海默病神经病理学的神经炎斑块和神经纤维缠结，以及动脉粥样硬化（一种潜在的可逆风险因素）是否会影响认知，而不依赖于脑梗死。我们在巴尔的摩老龄化纵向研究（BLSA）的200名参与者的尸检中检查了系统性动脉粥样硬化、阿尔茨海默型病理学和痴呆之间的关系，这是一项关于老龄化对认知影响的前瞻性研究，其中175人进行了完整的尸体解剖。通过对主动脉、心脏和颅内血管中动脉粥样硬化的定量分析，我们发现这些系统中动脉粥样硬化的程度与阿尔茨海默氏症型脑病理学的程度之间没有关系。然而，我们发现颅内动脉粥样硬化而非冠状动脉或主动脉粥样硬化的存在显著增加了痴呆的几率，与脑梗死无关。考虑到该队列中颅内动脉粥样硬化患者的数量较多（136/200），与颅内动脉粥样硬化相关的痴呆（与梗死无关）的人群归因风险很大且可能可逆。颅内动脉粥样硬化是痴呆症的一个独立和重要的危险因素，这表明与阿尔茨海默病病理学和中风无关的潜在可逆途径，血管变化可能会影响痴呆症的风险。
Although it is now accepted that asymptomatic cerebral infarcts are an important cause of dementia in the elderly, the relationship between atherosclerosis per se and dementia is controversial. Specifically, it is unclear whether atherosclerosis can cause the neuritic plaques and neurofibrillary tangles that define Alzheimer neuropathology and whether atherosclerosis, a potentially reversible risk factor, can influence cognition independent of brain infarcts. We examined the relationship between systemic atherosclerosis, Alzheimer type pathology and dementia in autopsies from 200 participants in the Baltimore Longitudinal Study of Aging (BLSA), a prospective study of the effect of aging on cognition, 175 of whom had complete body autopsies. Using a quantitative analysis of atherosclerosis in the aorta, heart and intracranial vessels, we found no relationship between the degree of atherosclerosis in any of these systems and the degree of Alzheimer’s type brain pathology. However, we found that the presence of intracranial but not coronary or aortic atherosclerosis significantly increased the odds of dementia, independent of cerebral infarction. Given the large number of individuals with intracranial atherosclerosis in this cohort (136/200), the population attributable risk of dementia related to intracranial atherosclerosis (independent of infarction) is substantial and potentially reversible. Atherosclerosis of the intracranial arteries is an independent and important risk factor for dementia, suggesting potentially reversible pathways unrelated to Alzheimer’s pathology and stroke through which vascular changes may influence dementia risk.
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DOI：
10.1159/000089359
发表时间：
2005-01-01
期刊：
Cerebrovascular diseases (Basel, Switzerland)
影响因子：
--
作者：
Arenillas, Juan F;Alvarez-Sabin, Jose
通讯作者：
Alvarez-Sabin, Jose
DOI：
10.1196/annals.1433.026
发表时间：
2008-01-01
期刊：
MAILLARD REACTION: RECENT ADVANCES IN FOOD AND BIOMEDICAL SCIENCES
影响因子：
--
作者：
Maczurek, Annette;Shanmugam, Kirubakaran;Muench, Gerald
通讯作者：
Muench, Gerald
影响因子：
168.9
作者：
Esiri, MM;Nagy, Z;Smith, AD
通讯作者：
Smith, AD
影响因子：
9.9
作者：
Kawas, C;Gray, S;Zonderman, A
通讯作者：
Zonderman, A
影响因子：
9.9
作者：
Beeri, MS;Rapp, M;Haroutunian, V
通讯作者：
Haroutunian, V