Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: Implication for treatment of periodontal infection and halitosis.
Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: Implication for treatment of periodontal infection and halitosis.
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DOI：
10.1016/j.vaccine.2010.02.047
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发表时间：
2010-04-26
期刊：
影响因子：
5.5
通讯作者：
Huang, Chun-Ming
中科院分区：
文献类型：
--
作者：
Liu, Pei-Feng;Shi, Wenyuan;Zhu, Wenhong;Smith, Jeffery W.;Hsieh, Shie-Liang;Gallo, Richard L.;Huang, Chun-Ming
多剂量抗生素机械疗法是治疗牙周病的方法之一。然而，使用多剂量抗生素的治疗存在产生耐药菌株和体内菌群失衡的风险。我们提出了一种针对核梭杆菌外膜蛋白FOMA的免疫方法，核梭杆菌是口腔生物膜结构中的一种中心桥梁生物。FOMA的中和显著地抑制了由核镰刀菌与牙龈卟啉单胞菌(P.givalis)的种间相互作用所介导的细菌共聚集、生物被膜和挥发性硫化合物的产生。针对FOMA的疫苗接种也对联合感染引起的牙周炎具有保护作用。在这里，我们提出了一种新的感染机制，通过这种机制，核假单胞菌与牙龈假单胞菌共同作用，加剧了牙龈感染。FOMA被强调为开发治疗人类牙周感染和口臭的新疗法的潜在靶点。
The mechanical therapy with multiple doses of antibiotics is one of modalities for treatment of periodontal diseases. However, treatments using multiple doses of antibiotics carry risks of generating resistant strains and misbalancing the resident body flora. We present an approach via immunization targeting an outer membrane protein FomA of Fusobacterium nucleatum, a central bridging organism in the architecture of oral biofilms. Neutralization of FomA considerably abrogated the enhancement of bacterial co-aggregation, biofilms and production of volatile sulfur compounds mediated by an interspecies interaction of F. nucleatum with Porphyromonas gingivalis (P. gingivalis). Vaccination targeting FomA also conferred a protective effect against co-infection-induced gum inflammation. Here, we advance a novel infectious mechanism by which F. nucleatum co-opts P. gingivalis to exacerbate gum infections. FomA is highlighted as a potential target for development of new therapeutics against periodontal infection and halitosis in humans.
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影响因子：
2.3
作者：
Liu PF;Zhu WH;Huang CM
通讯作者：
Huang CM
一种针对脓肿和晕骨的新型疫苗，靶向核细菌。
影响因子：
5.5
作者：
Liu PF;Haake SK;Gallo RL;Huang CM
通讯作者：
Huang CM
影响因子：
3.1
作者：
Baker, PJ;Dixon, M;Roopenian, DC
通讯作者：
Roopenian, DC
影响因子：
6.7
作者：
Kim, Do Young;Jun, Ji-Hae;Han, Soo-Boo
通讯作者：
Han, Soo-Boo
影响因子：
3.1
作者：
MALLISON, SM;SMITH, JP;TEW, JG
通讯作者：
TEW, JG