The antigenic evolution of influenza: drift or thrift?
The antigenic evolution of influenza: drift or thrift?
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DOI：
10.1098/rstb.2012.0200
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发表时间：
2013-03-19
期刊：
影响因子：
--
通讯作者：
Gupta S
中科院分区：
文献类型：
--
作者：
Wikramaratna PS;Sandeman M;Recker M;Gupta S
通常认为，针对流感病毒的抗体反应以以下方式极化：强抗体反应针对高度可变的抗原表位，因此经历“抗原漂移”，而弱抗体反应针对保守的表位。由于高度可变的表位处于不断变化的状态，目前基于抗体的疫苗策略主要集中在保守的表位上，期望在适当增强后它们将提供一定程度的临床保护。在这里，我们使用一个理论模型来提示低变异性表位的存在，这引发了高度的临床和传播阻断免疫。我们发现，流感的几个流行病学特征及其血清学和分子特征与这种“抗原性节俭”模型是一致的，并且鉴定这种模型预测的低变异性的保护性表位可以提供一种更可行的替代方案，以定期更新流感疫苗，而不是利用对弱免疫原性保守区域的反应。
It is commonly assumed that antibody responses against the influenza virus are polarized in the following manner: strong antibody responses are directed at highly variable antigenic epitopes, which consequently undergo ‘antigenic drift’, while weak antibody responses develop against conserved epitopes. As the highly variable epitopes are in a constant state of flux, current antibody-based vaccine strategies are focused on the conserved epitopes in the expectation that they will provide some level of clinical protection after appropriate boosting. Here, we use a theoretical model to suggest the existence of epitopes of low variability, which elicit a high degree of both clinical and transmission-blocking immunity. We show that several epidemiological features of influenza and its serological and molecular profiles are consistent with this model of ‘antigenic thrift’, and that identifying the protective epitopes of low variability predicted by this model could offer a more viable alternative to regularly update the influenza vaccine than exploiting responses to weakly immunogenic conserved regions.
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