Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency.
Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency.
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DOI：
10.1016/j.neuroscience.2014.04.069
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发表时间：
2014-07-11
期刊：
影响因子：
3.3
通讯作者：
Yan, L.
中科院分区：
文献类型：
--
作者：
Deats, S. P.;Adidharma, W.;Lonstein, J. S.;Yan, L.
光对情绪有深远的影响，例如季节性情感障碍（SAD）和明亮的光疗法的有益效果。然而，光调节情绪的潜在神经通路还没有得到很好的理解。我们以前的工作已经开发了一个昼夜草鼠，Arvicanthis niloticus，作为SAD的动物模型。通过利用模拟冬季较低光照强度的12：12小时昏暗：黑暗（DLD）范例，我们表明，与白天（BLD）在明亮光线下饲养的动物相比，在DLD中饲养的动物在强迫游泳试验（FST）和甜味溶液偏好（SSP）中表现出增加的抑郁样行为。本研究的目的是测试的假设，即光影响情绪的作用于大脑食欲素能系统的昼夜草鼠模型的SAD。首先，在DLD和BLD草大鼠中检查食欲素A免疫反应性（OXA-ir）。结果显示，与BLD组相比，DLD组动物下丘脑中OXA-免疫阳性神经元的数量减少，中缝背核中OXA-免疫阳性纤维密度减弱。然后，用SB-334867（一种选择性食欲素1受体（OX 1 R）拮抗剂）对BLD动物进行全身给药，与溶媒给药对照组相比，SB-334867导致抑郁表型，其特征为FST不动性增加和SSP降低。结果表明，衰减orexinergic信号与草鼠抑郁样行为增加，并支持的假设，orexinergic系统介导的光对情绪的影响。
Light has profound effects on mood, as exemplified by seasonal affective disorder (SAD) and the beneficial effects of bright light therapy. However, the underlying neural pathways through which light regulates mood are not well understood. Our previous work has developed the diurnal grass rat, Arvicanthis niloticus, as an animal model of SAD. By utilizing a 12:12hr Dim Light:Dark (DLD) paradigm that simulates the lower light intensity of winter, we showed that the animals housed in DLD exhibited increased depression-like behaviors in the forced swim test (FST) and sweet solution preference (SSP) compared to animals housed in bright light during the day (BLD). The objective of the present study was to test the hypothesis that light affects mood by acting on the brain orexinergic system in the diurnal grass rat model of SAD. First, orexinA immunoreactivity (OXA-ir) was examined in DLD and BLD grass rats. The results revealed a reduction in the number of OXA-ir neurons in the hypothalamus and attenuated OXA-ir fiber density in the dorsal raphe nucleus of animals in the DLD compared to those in the BLD group. Then, the animals in BLD were treated systemically with SB-334867, a selective orexin 1 receptor (OX1R) antagonist, which led to a depressive phenotype characterized by increased immobility in the FST and a decrease in SSP compared to vehicle-treated controls. The results suggest that attenuated orexinergic signaling is associated with increased depression-like behaviors in grass rats, and support the hypothesis that the orexinergic system mediates the effects of light on mood.
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影响因子：
2.7
作者：
Herrero, Ana I.;Sandi, Carmen;Venero, Cesar
通讯作者：
Venero, Cesar
影响因子：
64.8
作者：
Harris, GC;Wimmer, M;Aston-Jones, G
通讯作者：
Aston-Jones, G
DOI：
10.1073/pnas.96.2.748
发表时间：
1999-01-19
影响因子：
11.1
作者：
Date, Y;Ueta, Y;Nakazato, M
通讯作者：
Nakazato, M
影响因子：
3.3
作者：
Deurveilher, S;Semba, K
通讯作者：
Semba, K
新生儿给予氯米帕明引起的抑郁症大鼠模型中脑甲状腺素水平的变化。
DOI：
10.1177/0269881106082899
发表时间：
2008-09
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Feng P;Vurbic D;Wu Z;Hu Y;Strohl KP
通讯作者：
Strohl KP