Biosensing with DNAzymes.

Biosensing with DNAzymes.
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DOI:
10.1039/d1cs00240f
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发表时间:
2021-08-21
影响因子:
46.2
通讯作者:
--
中科院分区:
化学1区
文献类型:
--
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本文提供了一个全面的审查与DNA酶的生物传感,提供了不同的传感应用的概述,同时突出了便携式生物传感器设备和床旁诊断领域的重大进展和开创性贡献。具体而言,介绍了功能性核酸领域,特别关注DNA酶。将DNA酶纳入生物测定,然后描述,随后详细概述了在体内传感平台和便携式传感器的发展,将DNA酶的分子识别的最新进展。最后,一个关键的角度来看,该领域,并提供了一个摘要,其中DNA酶为基础的设备可能会产生最大的影响。
This article provides a comprehensive review of biosensing with DNAzymes, providing an overview of different sensing applications while highlighting major progress and seminal contributions to the field of portable biosensor devices and point-of-care diagnostics. Specifically, the field of functional nucleic acids is introduced, with a specific focus on DNAzymes. The incorporation of DNAzymes into bioassays is then described, followed by a detailed overview of recent advances in the development of in vivo sensing platforms and portable sensors incorporating DNAzymes for molecular recognition. Finally, a critical perspective on the field, and a summary of where DNAzyme-based devices may make the biggest impact are provided.
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