Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.
Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.
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DOI：
10.1371/journal.pone.0029141
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Nagaoka H
中科院分区：
文献类型：
--
作者：
Qin H;Suzuki K;Nakata M;Chikuma S;Izumi N;Huong le T;Maruya M;Fagarasan S;Busslinger M;Honjo T;Nagaoka H
由Aicda基因产生的激活诱导的胞苷脱氨酶（AID）是形成免疫记忆的免疫球蛋白基因（IG）改变所必需的。使用Cre介导的遗传系统，我们意外地发现了表达Aicda的CD 4 + T细胞（exAID细胞）以及B细胞。ExAID细胞随着年龄的增长而增加，达到CD 4+和B220+细胞群体的25%。ExAID B细胞保持IgM+，表明类别转换记忆B细胞不在脾脏中积累。在T细胞中，AID在产生IFN-γ和IL-10但很少产生IL-4或IL-17的亚群中表达，并且没有显示出遗传突变的证据。有趣的是，在没有B细胞的情况下，T细胞中的内源性Aicda表达增强，表明该过程独立于生发中心反应。这些结果表明，除了在B细胞中的作用，AID可能在T细胞功能或肿瘤发生中具有以前未被认识到的作用。
Activation-induced cytidine deaminase (AID), produced by the Aicda gene, is essential for the immunoglobulin gene (Ig) alterations that form immune memory. Using a Cre-mediated genetic system, we unexpectedly found CD4+ T cells that had expressed Aicda (exAID cells) as well as B cells. ExAID cells increased with age, reaching up to 25% of the CD4+ and B220+ cell populations. ExAID B cells remained IgM+, suggesting that class-switched memory B cells do not accumulate in the spleen. In T cells, AID was expressed in a subset that produced IFN-γ and IL-10 but little IL-4 or IL-17, and showed no evidence of genetic mutation. Interestingly, the endogenous Aicda expression in T cells was enhanced in the absence of B cells, indicating that the process is independent from the germinal center reaction. These results suggest that in addition to its roles in B cells, AID may have previously unappreciated roles in T-cell function or tumorigenesis.
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DOI：
10.1084/jem.20091442
发表时间：
2009-08-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Locksley RM
通讯作者：
Locksley RM
影响因子：
30.5
作者：
Dogan, Ismail;Bertocci, Barbara;Weill, Jean-Claude
通讯作者：
Weill, Jean-Claude
DOI：
10.1073/pnas.1102571108
发表时间：
2011-07-12
影响因子：
11.1
作者：
Kuraoka, Masayuki;Holl, T. Matt;Kelsoe, Garnett
通讯作者：
Kelsoe, Garnett
影响因子：
4.3
作者：
Lee, WT;Pelletier, WJ
通讯作者：
Pelletier, WJ
DOI：
10.4049/jimmunol.0901548
发表时间：
2009-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kuraoka M;Liao D;Yang K;Allgood SD;Levesque MC;Kelsoe G;Ueda Y
通讯作者：
Ueda Y