New clues in the nucleus: transcriptional reprogramming in effector-triggered immunity.
New clues in the nucleus: transcriptional reprogramming in effector-triggered immunity.
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DOI：
10.3389/fpls.2013.00364
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发表时间：
2013-09-13
影响因子：
5.6
通讯作者：
Gassmann W
中科院分区：
文献类型：
--
作者：
Bhattacharjee S;Garner CM;Gassmann W
植物效应子触发的免疫的稳健性与宿主转录组的大规模改变相关。然而，导致这种重编程的分子机制仍然不清楚。在这里，我们将回顾破译植物免疫受体和相关蛋白质核功能的最新进展。重要的悬而未决的问题仍然存在，例如参与控制效应子触发的免疫反应的主要转录因子的身份，以及这是否可以推广，或者特定的效应子-抗性蛋白相互作用是否会影响转录反应网络中的不同部分。多种证据表明 WRKY 转录因子是对微生物相关分子模式反应的核心，并与效应子触发的免疫相交叉。酵母双杂交研究的最新发现表明 TCP 转录因子家族的成员是来自不同病原体的多个效应子的目标。可能会鉴定出直接或间接参与效应子触发免疫的其他转录因子家族。
The robustness of plant effector-triggered immunity is correlated with massive alterations of the host transcriptome. Yet the molecular mechanisms that cause and underlie this reprogramming remain obscure. Here we will review recent advances in deciphering nuclear functions of plant immune receptors and of associated proteins. Important open questions remain, such as the identities of the primary transcription factors involved in control of effector-triggered immune responses, and indeed whether this can be generalized or whether particular effector-resistance protein interactions impinge on distinct sectors in the transcriptional response web. Multiple lines of evidence have implicated WRKY transcription factors at the core of responses to microbe-associated molecular patterns and in intersections with effector-triggered immunity. Recent findings from yeast two-hybrid studies suggest that members of the TCP transcription factor family are targets of several effectors from diverse pathogens. Additional transcription factor families that are directly or indirectly involved in effector-triggered immunity are likely to be identified.
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