Neuroanatomical Changes Underlying Vertical HIV Infection in Adolescents
Neuroanatomical Changes Underlying Vertical HIV Infection in Adolescents
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青少年垂直 HIV 感染的神经解剖学变化
DOI：
10.3389/fimmu.2019.00814
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发表时间：
2019-04
影响因子：
7.3
通讯作者：
Gui Xien
中科院分区：
文献类型：
--
作者：
Yu Xiao;Gao Lei;Wang Haha;Yin Zhuang;Fang Jian;Chen Jing;Li Qiang;Xu Haibo;Gui Xien
目的：本研究旨在探讨人类免疫缺陷病毒(HIV)如何影响青少年的脑发育，哪些是脑的易感区域，以及这些脑结构变化与认知能力的关系。方法：应用结构磁共振成像技术对16例HIV感染儿童(平均年龄13.63岁)和25例非HIV感染儿童(平均年龄13.32岁)进行了灰质体积和皮质厚度的检测，其中12例进行了为期1年的重复脑磁共振扫描。对每个受试者进行了五项神经认知测试，以评估他们在不同领域的认知表现。结果：横断面研究表明，HIV感染儿童的灰质体积广泛减少(主要分布在双侧额叶、颞叶、岛叶和小脑)。皮质厚度的改变主要是由于右侧颞叶变薄，左侧枕叶增厚。纵向研究表明，HIV感染者1岁后灰质体积缩小主要发生在右侧前额叶、顶叶和运动区的高级功能区，皮质变薄的脑区为感觉运动皮质和边缘系统。双侧小脑灰质体积与威斯康星卡片分类测验成绩呈正相关，右侧背外侧前额叶皮质厚度与威斯康星卡片分类测验成绩呈负相关。结论：本研究发现HIV感染的青春期儿童表现出皮质成熟延迟和萎缩。这种皮质发育的异常模式可能是艾滋病毒感染儿童认知障碍的结构性基础。
Purpose: The aim of this study was to investigate how human immunodeficiency virus (HIV) affects brain development in adolescents, what are susceptible brain regions, and how these brain structural changes correlate with cognitive abilities. Methods: We used structural magnetic resonance imaging to examine gray matter volume and cortical thickness in 16 HIV-infected children (mean age = 13.63 years) and 25 HIV-exposed uninfected children (mean age = 13.32 years), 12 of them were subjected to a 1-year repetitive magnetic resonance scan of the brain. Five neurocognitive tests were performed on each subject to assess cognitive performance in different areas. Results: Cross-sectional studies showed that the gray matter volume of HIV-infected children was widely reduced (mainly in the bilateral frontal, temporal, and insular regions, and cerebellum). The changes in cortical thickness were mainly due to thinning of the right temporal lobe and thickening of the left occipital lobe. Longitudinal studies showed that the gray matter volume reduction of HIV-infected children after 1 year mainly occurs in the advanced functional area of the right prefrontal, parietal lobe and the motor area, cortical thinning of brain regions were sensorimotor cortex and the limbic system. The gray matter volume of the bilateral cerebellum was positively correlated with the performance of the Wisconsin Card Sorting Test, while the cortical thickness of the right dorsolateral prefrontal cortex was negatively correlated with this test. Conclusion: This study found that HIV-infected pubertal children showed a delayed cortical maturation with atrophy. This abnormal pattern of cortical development may be the structural basis for cognitive impairment in HIV-infected children.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
25
作者：
Sowell, ER;Peterson, BS;Toga, AW
通讯作者：
Toga, AW
影响因子：
4.2
作者：
Pfefferbaum A;Rogosa DA;Rosenbloom MJ;Chu W;Sassoon SA;Kemper CA;Deresinski S;Rohlfing T;Zahr NM;Sullivan EV
通讯作者：
Sullivan EV
影响因子：
8
作者：
Nozyce, ML;Lee, SS;Pelton, S
通讯作者：
Pelton, S
DOI：
10.1073/pnas.0502548102
发表时间：
2005-10-25
影响因子：
11.1
作者：
Thompson, PM;Dutton, RA;Becker, JT
通讯作者：
Becker, JT