The relationship between the evolution of microRNA targets and the length of their UTRs.
The relationship between the evolution of microRNA targets and the length of their UTRs.
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DOI：
10.1186/1471-2164-10-431
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发表时间：
2009-09-14
期刊：
影响因子：
4.4
通讯作者：
Gerstein M
中科院分区：
文献类型：
--
作者：
Cheng C;Bhardwaj N;Gerstein M
MicroRNAs(MiRNAs)是许多真核细胞中在转录后水平上调节基因表达的内源性小RNA分子。它们在动物中广泛而重要的作用是通过估计大约25%的基因是miRNA靶标来衡量的。我们在两种哺乳动物：人和小鼠中，系统地研究了miRNA调控与其靶标进化之间的关系。我们发现，具有较长3‘UTRs的基因受更多不同类型的miRNAs调控。相应地，这些基因在蛋白质水平上往往具有较慢的进化速度。看家基因是另一类进化缓慢的基因。然而，它们有一种明显不同的调节类型，具有较短的3‘UTRs以避免miRNA靶向。我们的分析表明，miRNA靶的双向进化机制是基于它们的细胞作用和它们的3‘UTRs的长度。在空间或时间上表达的功能关键基因受到miRNAs的严格调控。而看家基因，无论多么保守，都被选择具有较短的3‘UTRs，以避免miRNA调控。
MicroRNAs (miRNAs) are endogenous small RNA molecules that modulate the gene expression at the post-transcription levels in many eukaryotic cells. Their widespread and important role in animals is gauged by estimates that ~25% of all genes are miRNA targets. We perform a systematic investigation of the relationship between miRNA regulation and their targets' evolution in two mammals: human and mouse. We find genes with longer 3' UTRs are regulated by more distinct types of miRNAs. These genes correspondingly tend to have slower evolutionary rates at the protein level. Housekeeping genes are another class of genes that evolve slowly. However, they have a distinctly different type of regulation, with shorter 3'UTRs to avoid miRNA targeting. Our analysis suggests a two-way evolutionary mechanism for miRNA targets on the basis of their cellular roles and the length of their 3' UTRs. Functionally critical genes that are spatially or temporally expressed are stringently regulated by miRNAs. While housekeeping genes, however conserved, are selected to have shorter 3'UTRs to avoid miRNA regulation.
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