Design strategies for aptamer-based biosensors.
Design strategies for aptamer-based biosensors.
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DOI:
10.3390/s100504541
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发表时间:
2010
期刊:
影响因子:
--
通讯作者:
Zhou N
中科院分区:
文献类型:
--
作者:
Han K;Liang Z;Zhou N
Aptamers have been widely used as recognition elements for biosensor construction, especially in the detection of proteins or small molecule targets, and regarded as promising alternatives for antibodies in bioassay areas. In this review, we present an overview of reported design strategies for the fabrication of biosensors and classify them into four basic modes: target-induced structure switching mode, sandwich or sandwich-like mode, target-induced dissociation/displacement mode and competitive replacement mode. In view of the unprecedented advantages brought about by aptamers and smart design strategies, aptamer-based biosensors are expected to be one of the most promising devices in bioassay related applications.
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