Novel insights into the behavioral analysis of mice subjected to the forced-swim test.
Novel insights into the behavioral analysis of mice subjected to the forced-swim test.
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DOI:
10.1038/tp.2015.44
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发表时间:
2015-04-14
影响因子:
6.8
通讯作者:
Mody I
中科院分区:
文献类型:
--
作者:
Chen L;Faas GC;Ferando I;Mody I
The forced-swim test (FST) is one of the most widely used rodent behavioral assays, in which the immobility of animals is used to assess the effectiveness of antidepressant drugs. However, the existing, and mostly arbitrary, criteria used for quantification could lead to biased results. Here we believe we uncovered new confounding factors, revealed new indices to interpret the behavior of mice and propose an unbiased means for quantification of the FST.
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