Novel insights into the behavioral analysis of mice subjected to the forced-swim test.

Novel insights into the behavioral analysis of mice subjected to the forced-swim test.
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DOI:
10.1038/tp.2015.44
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发表时间:
2015-04-14
影响因子:
6.8
通讯作者:
Mody I
Mody I
中科院分区:
医学1区
文献类型:
--
作者:
Chen L;Faas GC;Ferando I;Mody I

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强迫游泳试验(FST)是最广泛使用的啮齿动物行为试验之一,其中动物的不动性被用来评估抗抑郁药物的有效性。然而,现有的,而且大多是任意的,用于量化的标准可能导致有偏见的结果。在这里,我们相信我们发现了新的混杂因素,揭示了新的指标来解释小鼠的行为,并提出了一个公正的手段量化的FST。
The forced-swim test (FST) is one of the most widely used rodent behavioral assays, in which the immobility of animals is used to assess the effectiveness of antidepressant drugs. However, the existing, and mostly arbitrary, criteria used for quantification could lead to biased results. Here we believe we uncovered new confounding factors, revealed new indices to interpret the behavior of mice and propose an unbiased means for quantification of the FST.
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