Lack of association between methionine synthase A2756G polymorphism and digestive system cancer risk: evidence from 3,9327 subjects.
Lack of association between methionine synthase A2756G polymorphism and digestive system cancer risk: evidence from 3,9327 subjects.
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DOI：
10.1371/journal.pone.0061511
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wang XF
中科院分区：
文献类型：
--
作者：
Zhao Y;Chen Z;Ma Y;Xia Q;Zhang F;Fu D;Wang XF
参与叶酸和甲基代谢的基因多态性与消化系统癌症的风险有关。甲硫氨酸合酶（MTR）在叶酸代谢中起着重要作用，从而影响DNA甲基化。MTR基因A2756 G多态性（rs 1805087）与消化系统肿瘤易感性的关系在以往的研究中并不一致。为了研究这种不一致性，我们进行了这项荟萃分析。检索Pubmed、EMBASE、ISI Web of Science和中国知网（CNKI）等数据库，查找相关研究。比值比（OR）和95%置信区间（CI）用于评估关联强度。还通过亚组分析和荟萃回归评估了异质性的潜在来源。共纳入29篇文章，包括15，368例患者和23，959例对照。MTR A2756 G多态性与消化系统恶性肿瘤无相关性（G等位基因：OR = 1.03，95%CI = 0.98-1.09，P = 0.25;显性模型：OR = 1.03，95%CI = 0.97-1.10，P = 0.33;隐性模型：OR = 1.02，95%CI = 0.89-1.17，P = 0.79）。 在根据癌症类型、样本量和基因分型方法进行的分层分析中，几乎所有遗传模型均未获得任何基因-疾病关联的证据。然而，在东亚患者和基于医院的研究中发现了边缘显著相关性。这项荟萃分析表明，MTR A2756 G多态性与消化系统癌症风险之间没有显着关联。
Polymorphisms in genes involved in the metabolism of folate and methyl groups have been implicated with risk of digestive system cancer. Methionine synthase (MTR) plays a central role in folate metabolism, thereby affecting DNA methylation. The association between A2756G polymorphism (rs1805087) in MTR and digestive system cancer susceptibility was inconsistent in previous studies. To investigate this inconsistency, we performed this meta-analysis. Databases including Pubmed, EMBASE, ISI Web of Science and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Potential sources of heterogeneity were also assessed by subgroup analysis and meta-regression. A total of 29 articles with 15,368 patients and 23,959 controls were included. We found no association between MTR A2756G polymorphism and digestive system cancer in overall population (G allele: OR = 1.03, 95% CI = 0.98–1.09, P = 0.25; dominant model: OR = 1.03, 95% CI = 0.97–1.10, P = 0.33; recessive model: OR = 1.02, 95% CI = 0.89–1.17, P = 0.79). In the stratified analyses according to cancer type, sample size and genotyping method, no evidence of any gene-disease association was obtained in almost all genetic models. However, marginal significant associations were found for East Asians and hospital-based studies. This meta-analysis suggests that there is no significant association between the MTR A2756G polymorphism and digestive system cancer risk.
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影响因子：
3.1
作者：
Jokic, Mladen;Brcic-Kostic, Krunoslav;Kapitanovic, Sanja
通讯作者：
Kapitanovic, Sanja
影响因子：
7.1
作者：
Guerreiro, Catarina Sousa;Carmona, Bruno;Cravo, Marilia
通讯作者：
Cravo, Marilia
影响因子：
50.5
作者：
Kanavos, P.
通讯作者：
Kanavos, P.
DOI：
10.1158/1055-9965.epi-09-0841
发表时间：
2010-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Eussen SJ;Vollset SE;Igland J;Meyer K;Fredriksen A;Ueland PM;Jenab M;Slimani N;Boffetta P;Overvad K;Tjønneland A;Olsen A;Clavel-Chapelon F;Boutron-Ruault MC;Morois S;Weikert C;Pischon T;Linseisen J;Kaaks R;Trichopoulou A;Zilis D;Katsoulis M;Palli D;Berrino F;Vineis P;Tumino R;Panico S;Peeters PH;Bueno-de-Mesquita HB;van Duijnhoven FJ;Gram IT;Skeie G;Lund E;González CA;Martínez C;Dorronsoro M;Ardanaz E;Navarro C;Rodríguez L;Van Guelpen B;Palmqvist R;Manjer J;Ericson U;Bingham S;Khaw KT;Norat T;Riboli E
通讯作者：
Riboli E
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N