Changes in subjective measures of appetite during 6 months of alternate day fasting with a low carbohydrate diet.
Changes in subjective measures of appetite during 6 months of alternate day fasting with a low carbohydrate diet.
复制标题
低碳水化合物饮食的6个月替代日禁食期间，食欲的主观度量变化。
DOI：
10.1016/j.clnesp.2020.10.007
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发表时间：
2021-03
影响因子：
3
通讯作者：
Varady KA
中科院分区：
文献类型：
--
作者：
Kalam F;Gabel K;Cienfuegos S;Wiseman E;Ezpeleta M;Pavlou V;Varady KA
隔日禁食（ADF）已被证明可以降低体重，并通过增加饱腹感来改善主观食欲。然而，目前尚不清楚的是，ADF期间的碳水化合物限制是否会通过帮助降低饥饿感来提供额外的减肥益处。因此，本研究考察了6个月ADF结合低碳水化合物饮食对空腹和餐后食欲评级的影响。肥胖成年人（n = 31）参加ADF（600千卡的“禁食日”与自由采食的“盛宴日”交替）与低碳水化合物背景饮食（30%碳水化合物，35%蛋白质和35%脂肪）。为期6个月的试验包括3个月的减肥期，随后是3个月的体重维持期。在ADF-低碳水化合物饮食6个月后，体重相对于基线降低了6.2 ± 1.0 kg（P < 0.01）。在整个研究过程中，主观饥饿感和饱腹感没有变化。第6个月时，空腹胰岛素相对于基线降低（P < 0.05）3.3 ± 1.3 μ IU/mL。空腹血糖和胰岛素抵抗在研究过程中保持不变。饥饿感和饱腹感与体重、血糖调节因子或能量摄入无关。这些发现表明，相对于基线，ADF与低碳水化合物饮食相结合与食欲的任何变化无关。Clinicaltrials.gov，NCT 03528317。
Alternate day fasting (ADF) has been shown to lower body weight and improve subjective appetite by increasing fullness. What remains unknown, however, is whether carbohydrate restriction during ADF would provide additional weight loss benefits by helping to lower hunger as well. Accordingly, this study examined the effect of 6-months of ADF combined with a low carbohydrate diet on fasting and postprandial appetite ratings. Adults with obesity (n = 31) participated in ADF (600 kcal “fast day” alternated with an ad libitum “feast day”) with a low-carbohydrate background diet (30% carbohydrates, 35% protein, and 35% fat). The 6-month trial consisted of a 3-month weight loss period followed by a 3-month weight maintenance period. After 6-months of an ADF-low carbohydrate diet, body weight decreased (P < 0.01) by 6.2 ± 1.0 kg, relative to baseline. Subjective hunger and fullness did not change throughout the study. Fasting insulin decreased (P < 0.05) by 3.3 ± 1.3 μlU/mL by month 6, relative to baseline. Fasting glucose and insulin resistance, remained unchanged over the course of the study. Hunger and fullness were not related to body weight, glucoregulatory factors or energy intake. These findings suggest that ADF combined with a low carbohydrate diet is not associated with any changes in appetite, relative to baseline. Clinicaltrials.gov, NCT03528317.
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影响因子：
39
作者：
Trepanowski JF;Kroeger CM;Barnosky A;Klempel MC;Bhutani S;Hoddy KK;Gabel K;Freels S;Rigdon J;Rood J;Ravussin E;Varady KA
通讯作者：
Varady KA
影响因子：
7.1
作者：
Varady, Krista A.;Bhutani, Surabhi;Klempel, Monica C.
通讯作者：
Klempel, Monica C.
影响因子：
7.1
作者：
Weigle, DS;Breen, PA;Purnell, JQ
通讯作者：
Purnell, JQ
影响因子：
3.6
作者：
Poslusna, Kamila;Ruprich, Jiri;van't Veer, Pieter
通讯作者：
van't Veer, Pieter
DOI：
10.1097/00075197-200311000-00005
发表时间：
2003-11-01
影响因子：
3.1
作者：
Westerterp-Plantenga, MS
通讯作者：
Westerterp-Plantenga, MS