Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care.
Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care.
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DOI：
10.1016/j.cell.2021.02.012
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发表时间：
2021-03-18
期刊：
影响因子：
64.5
通讯作者：
Zierath, Juleen R.
中科院分区：
文献类型：
--
作者：
Pillon, Nicolas J.;Loos, Ruth J. F.;Marshall, Sally M.;Zierath, Juleen R.
几十年来，2型糖尿病和肥胖症的患病率急剧上升，预计还会进一步上升，其次是日益老龄化的久坐人口。预计全球医疗保健的压力将是巨大的。本文综述了影响代谢的遗传和环境因素的最新研究成果和新思想。转化研究和临床应用，包括COVID-19大流行的影响，都得到了强调。展望未来，有必要制定个性化的预防、管理和护理战略，以改善健康状况，减少这些代谢性疾病的影响。成功遏制肥胖和2型糖尿病的上升需要详细了解影响个人的遗传和环境因素，以及广泛考虑地球仪社区面临的社会挑战，包括应对COVID-19。
The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases. Successful efforts to stem the rise in obesity and type 2 diabetes will require a detailed understanding of the genetic and environmental factors affecting individuals as well as a broad consideration of societal challenges, including responses to COVID-19, faced by communities across the globe.
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影响因子：
29
作者：
Barres, Romain;Yan, Jie;Zierath, Juleen R.
通讯作者：
Zierath, Juleen R.
影响因子：
44.5
作者：
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影响因子：
5.5
作者：
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影响因子：
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通讯作者：
Schibler, U
影响因子：
10.9
作者：
Cai, Dongsheng
通讯作者：
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