Human papillomavirus infection and sporadic breast carcinoma risk: a meta-analysis.
Human papillomavirus infection and sporadic breast carcinoma risk: a meta-analysis.
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DOI：
10.1007/s10549-010-1128-0
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发表时间：
2011-04
影响因子：
3.8
通讯作者：
Dai, Min
中科院分区：
文献类型：
--
作者：
Li, Ni;Bi, Xiaofeng;Zhang, Yawei;Zhao, Ping;Zheng, Tongzhang;Dai, Min
尽管近年来进行的分子流行病学研究数量增加，以评估HPV感染与乳腺癌风险之间的关系，但这些研究仍然没有定论。在这里，进行了荟萃分析，以估计HPV在乳腺癌中的患病率，并测试相关性。应用聚合酶链反应技术检测女性散发性乳腺癌中HPV DNA。需要关于总体和类型特异性（HPV 6、11、16、18、31、33、35、45和51）HPV患病率的信息，以及研究人群、HPV DNA来源、出版日历期和用于HPV DNA检测和分型的PCR引物的详细描述。我们发现24.49%的乳腺癌病例与HPV有关，32.42%发生在亚洲，12.91%发生在欧洲。四种最常见的HPV类型，按照患病率下降的顺序，是HPV 33，18，16和35。HPV的检出主要受发表时间和PCR引物的影响。此外，对10项病例对照研究（包括447例乳腺癌病例和275例对照）的分析显示，HPV阳性的乳腺癌风险显著增加（OR = 3.63，95%CI = 1.42-9.27）。这些结果表明，根据现有的文献证据，目前还难以排除HPV与乳腺癌相关的可能性。
Despite an increase in the number of molecular epidemiological studies conducted in recent years to evaluate the association between HPV infection and risk of breast carcinoma, the studies remain inconclusive. Here, a meta-analysis was conducted to estimate the prevalence of HPV in breast carcinoma and test the association. Studies on HPV DNA detection in sporadic breast carcinoma in female using polymerase chain reaction were included. Information on overall and type-specific (HPV 6, 11, 16, 18, 31, 33, 35, 45 and 51) HPV prevalence were required, plus detailed descriptions of study populations, HPV DNA source, publication calendar period and PCR primers used for HPV DNA detection and typing. We revealed that 24.49% of the breast carcinoma cases were associated with HPV, 32.42% occurred in Asia and 12.91% in Europe. The four most commonly identified HPV types, in the order of decreased prevalence, were HPV33, 18, 16, and 35. The detection of HPV was mostly influenced by publication calendar period and PCR primers used. In addition, the analysis of ten case–control studies containing 447 breast carcinoma cases and 275 controls showed a significant increase in breast carcinoma risk with HPV positivity (OR = 3.63, 95% CI = 1.42–9.27). These results suggest that it’s difficult to rule out the possibility of the association of HPV and breast carcinoma at present according to available publication proofs.
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影响因子：
3.8
作者：
DILONARDO, A;VENUTI, A;MARCANTE, ML
通讯作者：
MARCANTE, ML
影响因子：
3.8
作者：
Aceto, Gitana Maria;Rosaria Solano, Angela;Jorge Podesta, Ernesto
通讯作者：
Jorge Podesta, Ernesto
影响因子：
8.8
作者：
Akil, N.;Yasmeen, A.;Al Moustafa, A-E
通讯作者：
Al Moustafa, A-E
影响因子：
2.2
作者：
DerSimonian, Rebecca;Kacker, Raghu
通讯作者：
Kacker, Raghu
影响因子：
3.8
作者：
Mendizabal-Ruiz, A. P.;Morales, J. A.;Montoya-Fuentes, H.
通讯作者：
Montoya-Fuentes, H.