Beyond birth-weight: early growth and adolescent blood pressure in a Peruvian population.
Beyond birth-weight: early growth and adolescent blood pressure in a Peruvian population.
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作者：
Sterling R;Checkley W;Gilman RH;Cabrera L;Sterling CR;Bern C;Miranda JJ
背景。对成人原发性高血压起源的纵向调查发现，儿童血压升高可以准确地追踪到成年期，但青少年和成年期原发性高血压的直接原因尚不清楚。方法。我们重新研究了152名秘鲁青少年，他们来自一个出生队列，年龄从0到30个月，通过1995年至1998年间每月的人体测量来评估他们的生长情况，并在11-14年后获得了人体测量和血压测量值。我们使用多变量回归模型来研究婴幼儿生长趋势对青少年早期血压和中心性肥胖的影响。结果。在回归模型调整的临时改变体重和身高,体重每增加0.1 SD长度从0到5个月的年龄,和1 SD从6到30个月的年龄,增加与减少青少年1.3毫米汞柱的收缩压(95% CI 2.4−−0.1)和2.5毫米汞柱(95% CI 4.9−0.0),和减少腰围0.6 (95% CI 1.1−0.0)和1.2厘米(95% CI 2.3−−0.1),分别。婴儿期和幼儿期的生长与青少年腰臀比无显著相关。结论。生命早期的快速代偿性生长被认为会增加长期心血管疾病的风险，因此营养干预可能弊大于利。然而，我们发现婴儿期和幼儿期体重增加与青春期收缩压降低和中枢性肥胖有关。
Background. Longitudinal investigations into the origins of adult essential hypertension have found elevated blood pressure in children to accurately track into adulthood, however the direct causes of essential hypertension in adolescence and adulthood remains unclear. Methods. We revisited 152 Peruvian adolescents from a birth cohort tracked from 0 to 30 months of age, and evaluated growth via monthly anthropometric measurements between 1995 and 1998, and obtained anthropometric and blood pressure measurements 11–14 years later. We used multivariable regression models to study the effects of infantile and childhood growth trends on blood pressure and central obesity in early adolescence. Results. In regression models adjusted for interim changes in weight and height, each 0.1 SD increase in weight for length from 0 to 5 months of age, and 1 SD increase from 6 to 30 months of age, was associated with decreased adolescent systolic blood pressure by 1.3 mm Hg (95% CI −2.4 to −0.1) and 2.5 mm Hg (95% CI −4.9 to 0.0), and decreased waist circumference by 0.6 (95% CI −1.1 to 0.0) and 1.2 cm (95% CI −2.3 to −0.1), respectively. Growth in infancy and early childhood was not significantly associated with adolescent waist-to-hip ratio. Conclusions. Rapid compensatory growth in early life has been posited to increase the risk of long-term cardiovascular morbidities such that nutritional interventions may do more harm than good. However, we found increased weight growth during infancy and early childhood to be associated with decreased systolic blood pressure and central adiposity in adolescence.
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影响因子：
5.2
作者：
Jackson LV;Thalange NK;Cole TJ
通讯作者：
Cole TJ
影响因子：
8.3
作者：
Eriksson, J;Forsén, T;Barker, D
通讯作者：
Barker, D
影响因子：
2.8
作者：
Kark, Malin;Tynelius, Per;Rasmussen, Finn
通讯作者：
Rasmussen, Finn
影响因子：
5
作者：
Checkley, W;Epstein, LD;Black, RE
通讯作者：
Black, RE
DOI：
10.3945/ajcn.2008.27139
发表时间：
2009-05
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Adair LS;Martorell R;Stein AD;Hallal PC;Sachdev HS;Prabhakaran D;Wills AK;Norris SA;Dahly DL;Lee NR;Victora CG
通讯作者：
Victora CG