T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2.
T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2.
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T 淋巴细胞是保护免疫小鼠的阴道粘膜和感觉神经节免受 2 型单纯疱疹病毒再次感染所必需的。
DOI：
10.4049/jimmunol.160.12.6093
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发表时间：
1998
影响因子：
4.4
通讯作者：
N. Bourne
中科院分区：
文献类型：
--
作者：
G. Milligan;D. Bernstein;N. Bourne
阴道内接种的小鼠与减毒株的单纯疱疹病毒2型（HSV-2）导致了强烈的HSV特异性免疫反应，保护对随后的挑战与完全毒力HSV-2株。即使在高滴度的HSV特异性抗体的存在下，T细胞依赖性机制是保护HSV免疫小鼠的阴道粘膜所必需的，并且可以在阴道内再接种后24小时检测到。HSV-2再接种前HSV免疫小鼠特异性T细胞亚群的耗竭表明，CD 4 + T细胞主要负责这种保护。同样，感觉神经节对HSV-2再感染的最佳保护依赖于T细胞的存在。在仅耗尽CD 4+或CD 8 + T细胞的HSV免疫小鼠的感觉神经节或脊髓中未检测到感染性HSV-2，这表明T细胞介导的保护可由任一亚群提供。类似地，在HSV免疫小鼠的攻击期间IFN-γ的中和导致阴道粘膜的保护减少，但不是感觉神经节。这些结果表明，诱导强烈的HSV特异性T细胞应答的能力是设计保护阴道粘膜和感觉神经节免受HSV-2侵害的疫苗的重要考虑因素。
Intravaginal inoculation of mice with an attenuated strain of herpes simplex virus type 2 (HSV-2) resulted in vigorous HSV-specific immune responses that protected against subsequent challenge with fully virulent HSV-2 strains. Even in the presence of high titers of HSV-specific Ab, T cell-dependent mechanisms were required for protection of the vaginal mucosae of HSV-immune mice and could be detected by 24 h after intravaginal reinoculation. Depletion of specific T cell subsets from HSV-immune mice before HSV-2 reinoculation demonstrated that CD4+ T cells were primarily responsible for this protection. Similarly, optimal protection of the sensory ganglia against reinfection with HSV-2 was dependent on the presence of T cells. Infectious HSV-2 was not detected in the sensory ganglia or spinal cord of HSV-immune mice depleted of only CD4+ or CD8+ T cells, suggesting that the T cell-mediated protection could be provided by either subset. Similarly, neutralization of IFN-gamma during challenge of HSV-immune mice resulted in diminished protection of the vaginal mucosa, but not of the sensory ganglia. These results suggest that the ability to induce vigorous HSV-specific T cell responses is an important consideration in the design of vaccines to protect both the vaginal mucosa and sensory ganglia against HSV-2.
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影响因子：
56.9
作者：
STEVENS, JG;WAGNER, EK;FELDMAN, LT
通讯作者：
FELDMAN, LT
盆腔、肠胃外或阴道免疫后小鼠阴道液中的分泌性免疫反应。
影响因子：
6.4
作者：
Thapar,MA;Parr,EL;Parr,MB
通讯作者：
Parr,MB
巨噬细胞和其他非特异性防御：在调节单纯疱疹病毒抵抗力中的作用。
影响因子：
--
作者：
Wu,L;Morahan,PS
通讯作者：
Morahan,PS
影响因子：
6.4
作者：
G. Kolaitis;M. Doymaz;B. Rouse
通讯作者：
G. Kolaitis;M. Doymaz;B. Rouse
影响因子：
3.7
作者：
MILLIGAN, GN;BERNSTEIN, DI
通讯作者：
BERNSTEIN, DI