Salmonella enterica in the Chicken: How it has Helped Our Understanding of Immunology in a Non-Biomedical Model Species.
Salmonella enterica in the Chicken: How it has Helped Our Understanding of Immunology in a Non-Biomedical Model Species.
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DOI：
10.3389/fimmu.2014.00482
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发表时间：
2014
影响因子：
7.3
通讯作者：
Wigley P
中科院分区：
文献类型：
--
作者：
Wigley P
鸡的沙门氏菌感染作为食源性人类沙门氏菌病的来源和鸡本身的疾病来源都是重要的。疫苗接种和其他控制策略需要了解免疫应答，因此在了解粘膜免疫和更普遍的细菌感染应答方面非常重要。在这篇综述中，我们讨论了禽沙门氏菌病的研究所作的贡献，了解先天免疫，包括吞噬细胞，模式识别受体和防御素的功能。对沙门氏菌感染的粘膜反应及其调节，以及这在保护肠道免受感染和持久性方面的贡献，以及未来更好地理解TH17和Tclase在这种反应中的作用的方向。最后，我们讨论了免疫系统的作用及其调制在持续感染和生殖道感染。我们还概述了充分了解鸡免疫系统和沙门氏菌之间的相互作用以及在没有实质性胃肠道疾病的情况下如何维持感染所需的关键研究领域。
Salmonella infection of the chicken is important both as a source of foodborne human salmonellosis and as a source of disease in the chicken itself. Vaccination and other control strategies require an understanding of the immune response and as such have been important in understanding both mucosal immunity and more generally the response to bacterial infection. In this review, we discuss the contribution the study of avian salmonellosis has made to understanding innate immunity including the function of phagocytic cells, pattern recognition receptors, and defensins. The mucosal response to Salmonella infection and its regulation and the contribution this makes in protection against infection and persistence within the gut and future directions in better understanding the role of TH17 and Tregs in this response. Finally, we discuss the role of the immune system and its modulation in persistent infection and infection of the reproductive tract. We also outline key areas of research required to fully understand the interaction between the chicken immune system and Salmonella and how infection is maintained in the absence of substantive gastrointestinal disease.
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影响因子：
4.4
作者：
Del Cacho E;Gallego M;Lillehoj HS;Quílez J;Lillehoj EP;Ramo A;Sánchez-Acedo C
通讯作者：
Sánchez-Acedo C
影响因子：
3.1
作者：
Beal, RK;Powers, C;Smith, AL
通讯作者：
Smith, AL
影响因子：
2.8
作者：
Beal, RK;Powers, C;Smith, AL
通讯作者：
Smith, AL
影响因子：
3.1
作者：
Henderson, SC;Bouous, DI;Lee, MD
通讯作者：
Lee, MD
影响因子：
3.6
作者：
He, HQ;Genovese, KJ;Kogut, MH
通讯作者：
Kogut, MH