Blood oxygenation level-dependent (BOLD)-based techniques for the quantification of brain hemodynamic and metabolic properties - theoretical models and experimental approaches.
Blood oxygenation level-dependent (BOLD)-based techniques for the quantification of brain hemodynamic and metabolic properties - theoretical models and experimental approaches.
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DOI：
10.1002/nbm.2839
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发表时间：
2013-08
影响因子：
2.9
通讯作者：
He, Xiang
中科院分区：
文献类型：
--
作者：
Yablonskiy, Dmitriy A.;Sukstanskii, Alexander L.;He, Xiang
关键词：
定量评价脑血流动力学和代谢，特别是脑功能与氧利用之间的关系，对于了解人脑的正常运作以及神经系统疾病的病理生理学具有重要意义。它对评估脑肿瘤和其他器官内的缺氧也非常重要。小川及其同事的BOLD(血液氧合水平依赖)对比剂的一项基础性发现为利用这种效应通过核磁共振测量来研究大脑血液动力学和代谢特性提供了可能性。这种测量需要开发理论模型，将磁共振信号与大脑结构和功能联系起来，并设计实验技术，允许对理论模型的显著特征进行磁共振测量。在我们的综述中，我们讨论了几个这样的理论模型和实验方法，以量化脑血流动力学和代谢特性。本文主要针对基于血氧水平的氧提取分数(OEF)的测量方法进行综述。结合OEF和CBF的测量，可以评估氧耗，CMRO2。我们首先详细讨论了不同实验条件下血液磁化率的磁特性、MR弛豫以及血管内对MR信号贡献的理论模型。然后，我们描述了一种“穿透空间”效应--血管内脱氧血液在血管外空间产生的不均匀磁场对磁共振信号形成的影响。此外，我们还描述了利用这些理论模型的几种实验技术。其中一些技术--MR测压和基于T2的氧合指数量化--利用血管内MR信号。另一种技术-qBOLD-通过利用穿越空间效应来评估OEF。在这篇综述中，我们瞄准了刚刚进入磁共振领域的科学家和更有经验的磁共振研究人员，他们对应用先进的基于BOLD的技术来研究大脑的健康和疾病感兴趣。
Quantitative evaluation of brain hemodynamics and metabolism, particularly the relationship between brain function and oxygen utilization, is important for understanding normal human brain operation as well as pathophysiology of neurological disorders. It can also be of great importance for evaluation of hypoxia within tumors of the brain and other organs. A fundamental discovery by Ogawa and co-workers of the BOLD (Blood Oxygenation Level Dependent) contrast opened a possibility to use this effect to study brain hemodynamic and metabolic properties by means of MRI measurements. Such measurements require developing theoretical models connecting MRI signal to brain structure and functioning and designing experimental techniques allowing MR measurements of salient features of theoretical models. In our review we discuss several such theoretical models and experimental methods for quantification brain hemodynamic and metabolic properties. Our review aims mostly at methods for measuring oxygen extraction fraction, OEF, based on measuring blood oxygenation level. Combining measurement of OEF with measurement of CBF allows evaluation of oxygen consumption, CMRO2. We first consider in detail magnetic properties of blood – magnetic susceptibility, MR relaxation and theoretical models of intravascular contribution to MR signal under different experimental conditions. Then, we describe a “through-space” effect – the influence of inhomogeneous magnetic fields, created in the extravascular space by intravascular deoxygenated blood, on the MR signal formation. Further we describe several experimental techniques taking advantage of these theoretical models. Some of these techniques - MR susceptometry, and T2-based quantification of oxygen OEF – utilize intravascular MR signal. Another technique – qBOLD – evaluates OEF by making use of through-space effects. In this review we targeted both scientists just entering the MR field and more experienced MR researchers interested in applying advanced BOLD-based techniques to study brain in health and disease.
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影响因子：
3.3
作者：
Buckley, David L.;Kershaw, Lucy E.;Stanisz, Greg J.
通讯作者：
Stanisz, Greg J.
影响因子：
3.3
作者：
CHU, SCK;XU, Y;SPRINGER, CS
通讯作者：
SPRINGER, CS
影响因子：
5.7
作者：
Blockley, Nicholas P.;Griffeth, Valerie E. M.;Buxton, Richard B.
通讯作者：
Buxton, Richard B.
DOI：
10.1124/jpet.112.192138
发表时间：
2012-09-01
影响因子：
3.5
作者：
Johri, Ashu;Beal, M. Flint
通讯作者：
Beal, M. Flint
影响因子：
6.3
作者：
Chen, J. Jean;Pike, G. Bruce
通讯作者：
Pike, G. Bruce