Ethylene oxide: an assessment of the epidemiological evidence on carcinogenicity.
Ethylene oxide: an assessment of the epidemiological evidence on carcinogenicity.
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环氧乙烷：对致癌性流行病学证据的评估。
DOI：
10.1136/oem.50.11.971
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Pannett,B
中科院分区：
文献类型：
--
作者：
Shore,RE;Gardner,MJ;Pannett,B
对接触环氧乙烷（EtO）的工人的癌症死亡率进行了10个不同队列的研究，其中包括约29,800名工人和2540名死亡人员。本文对这些研究进行综述和荟萃分析，主要针对白血病、非霍奇金淋巴瘤、胃癌、胰腺癌以及脑癌和神经系统癌。评估了单独研究和联合研究的标准化死亡率（smr）的幅度和一致性，以及暴露强度或频率、暴露持续时间和潜伏期（自首次暴露以来的时间）的趋势。暴露于其他工作场所化学物质作为可能的混杂变量进行了检查。Hogstedt的三个小型研究最初提出了EtO与白血病之间的联系，但在随后的七项研究中，白血病的smr要低得多。对于联合研究，SMR = 1.06（95%置信区间（95% CI） 0.73-1.48）。暴露时间有轻微的趋势（p = 0.19），暴露时间越长，白血病风险越高（p = 0.07），但暴露强度或暴露频率对白血病风险没有总体趋势；在最大规模的研究中，累积暴露分析也没有显示出定量关联。还有迹象表明，在两项风险增加的研究中，工人暴露于其他潜在的致癌物中。对于非霍奇金淋巴瘤，总体上存在提示风险（SMR = 1.35, 95% CI 0.93-1.90）。暴露强度或频率、暴露持续时间或潜伏期的分析没有显示出相关性，但在最大的研究中，累积暴露显示出正趋势（p = 0.05）。研究表明，胃癌的总体SMR增加（SMR = 1.28, 95% CI 0.98-1.65（考虑到风险估计的异质性，CI 0.73-2.26）），但暴露强度或持续时间或累积暴露的分析不支持胃癌的因果关系。总体SMR和暴露反应分析没有显示EtO对胰腺癌（SMR = 0.98）、脑和神经系统癌（SMR = 0.89）或总癌（SMR = 0.94）的风险。虽然目前的数据没有提供一致和令人信服的证据，证明EtO会导致白血病或非霍奇金淋巴瘤，但这些问题尚未解决，需要对暴露人群进行进一步的研究。
Mortality from cancer among workers exposed to ethylene oxide (EtO) has been studied in 10 distinct cohorts that include about 29,800 workers and 2540 deaths. This paper presents a review and meta-analysis of these studies, primarily for leukaemia, non-Hodgkin's lymphoma, stomach cancer, pancreatic cancer, and cancer of the brain and nervous system. The magnitude and consistency of the standardised mortality ratios (SMRs) were evaluated for the individual and combined studies, as well as trends by intensity or frequency of exposure, by duration of exposure, and by latency (time since first exposure). Exposures to other workplace chemicals were examined as possible confounder variables. Three small studies by Hogstedt initially suggested an association between EtO and leukaemia, but in seven subsequent studies the SMRs for leukaemia have been much lower. For the combined studies the SMR = 1.06 (95% confidence interval (95% CI) 0.73-1.48). There was a slight suggestion of a trend by duration of exposure (p = 0.19) and a suggested increase with longer latency (p = 0.07), but there was no overall trend in risk of leukaemia by intensity or frequency of exposure; nor did a cumulative exposure analysis in the largest study indicate a quantitative association. There was also an indication that in two studies with increased risks the workers had been exposed to other potential carcinogens. For non-Hodgkin's lymphoma there was a suggestive risk overall (SMR = 1.35, 95% CI 0.93-1.90). Breakdowns by exposure intensity or frequency, exposure duration, or latency did not indicate an association, but a positive trend by cumulative exposure (p = 0.05) was seen in the largest study. There was a suggested increase in the overall SMR for stomach cancer (SMR = 1.28, 95% CI 0.98-1.65 (CI 0.73-2.26 when heterogeneity among the risk estimates was taken into account)), but analyses by intensity or duration of exposure or cumulative exposure did not support a causal association for stomach cancer. The overall SMRs and exposure-response analyses did not indicate a risk from EtO for pancreatic cancer (SMR = 0.98), brain and nervous system cancer (SMR = 0.89), or total cancer (SMR = 0.94). Although the current data do not provide consistent and convincing evidence that EtO causes leukaemia or non-Hodgkin's lymphoma, the issues are not resolved and await further studies of exposed populations.
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对接触环氧乙烷的工人进行的多中心死亡率研究。
DOI：
10.1136/oem.47.3.182
发表时间：
1990
期刊：
British Journal of Industrial Medicine
影响因子：
--
作者：
N. Kiesselbach;K. Ulm;H;U. Korallus;Arztliche Abteilung;AG Bayer;D;Dietrich Plant No 40 Bayer;Leverkusen Ag;Frankfurt Hoechst AG;M. J. Stasik;Plant No;Gendorf H Hoglmeier;Ag Basf;G. LudwigshafenW;Stocker
通讯作者：
Stocker
化学制造中环氧乙烷工人的死亡率研究：十年更新。
DOI：
10.1136/oem.50.8.704
发表时间：
1993
期刊：
British Journal of Industrial Medicine
影响因子：
--
作者：
M. Teta;L. Benson;J. Vitale
通讯作者：
J. Vitale
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
环氧乙烷工人的死亡率。
DOI：
10.1097/00043764-198111000-00011
发表时间：
1981
期刊：
Journal of occupational medicine. : official publication of the Industrial Medical Association
影响因子：
--
作者：
R. W. Morgan;K. Claxton;B. J. Divine;S. Kaplan;V. B. Harris
通讯作者：
V. B. Harris
职业癌症：解释人类证据的问题
影响因子：
--
作者：
R. Doll
通讯作者：
R. Doll