The interplay of stress and electrocortical reactivity to reward in the prospective prediction of depression symptoms during COVID-19.
The interplay of stress and electrocortical reactivity to reward in the prospective prediction of depression symptoms during COVID-19.
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DOI：
10.1016/j.jpsychires.2021.05.034
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发表时间：
2021-08
影响因子：
4.8
通讯作者：
Burkhouse KL
中科院分区：
文献类型：
--
作者：
Feurer C;Granros M;Calentino AE;Suor JH;Patel K;Burkhouse KL
在2019年新型冠状病毒病（COVID-19）大流行期间，抑郁症的发病率有所增加，可能是由于相关的压力暴露。然而，目前还不清楚哪些人最容易受到影响。奖励处理的皮层电标记，如奖励积极性（RewP），与抑郁风险有关，并可能提供关于谁在COVID-19大流行期间最容易受到压力的见解。目前的研究检查了大流行前奖励反应的神经相关性（即，RewP）缓和了社会和经济压力对流行病爆发前后青年和母亲抑郁症状变化的影响。当前样本中的青年（n = 45）和母亲（n = 45）是在COVID-19大流行之前招募的，作为一项更大规模研究的一部分。在大流行前对RewP进行了评估，在大流行发作前后对青年和母亲的抑郁症状进行了评估。此外，社会和金融慢性压力的严重程度进行了评估后，流行病发作使用的修改版本的加州大学洛杉矶分校的生活压力访谈。对于基线时表现出RewP钝化的青年，经济压力与抑郁症的预期增加相关。同样，家庭压力与母亲在基线时表现出钝化RewP的抑郁症状的预期增加有关。研究结果表明，在大流行的背景下，当暴露于更高水平的压力时，神经水平的奖励反应性降低可能使年轻人和母亲更容易出现未来的抑郁症状。
Rates of depression have increased during the novel coronavirus disease 2019 (COVID-19) pandemic, potentially due to associated stress exposure. However, it remains unclear which individuals are most susceptible. Electrocortical markers of reward processing, such as the reward positivity (RewP), are implicated in depression risk and may provide insights into who is most vulnerable to stress during the COVID-19 pandemic. The current study examined whether pre-pandemic neural correlates of reward reactivity (i.e., RewP) moderated the impact of social and financial stress on changes in youth and mother depression symptoms pre-to-post pandemic onset. Youth (n = 45) and mothers (n = 45) in the current sample were recruited prior to the COVID-19 pandemic as part of a larger study. RewP was assessed pre-pandemic, and depression symptoms were assessed pre- and post-pandemic onset for both youth and mothers. Additionally, social and financial chronic stress severity was assessed post-pandemic onset using a modified version of the UCLA Life Stress Interview. Financial stress was associated with prospective increases in depression for youth exhibiting blunted RewP at baseline. Similarly, family stress was associated with prospective increases in depression symptoms for mothers exhibiting blunted RewP at baseline. Findings suggest reduced reward responsiveness at the neural level may predispose both youth and mothers to future depression symptoms when exposed to higher levels of stress in the context of a pandemic.
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影响因子：
5.9
作者：
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