Gibbon genome and the fast karyotype evolution of small apes.
Gibbon genome and the fast karyotype evolution of small apes.
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DOI：
10.1038/nature13679
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发表时间：
2014-09-11
期刊：
影响因子：
64.8
通讯作者：
Gibbs, Richard A.
中科院分区：
文献类型：
--
作者：
Carbone, Lucia;Harris, R. Alan;Gnerre, Sante;Veeramah, Krishna R.;Lorente-Galdos, Belen;Huddleston, John;Meyer, Thomas J.;Herrero, Javier;Roos, Christian;Aken, Bronwen;Anaclerio, Fabio;Archidiacono, Nicoletta;Baker, Carl;Barre, Daniel;Batzer, Marka.;Beal, Kathryn;Blancher, Antoine;Bohrson, Craig L.;Brameier, Markus;Campbell, Michael S.;Capozzi, Oronzo;Casola, Claudio;Chiatante, Giorgia;Cree, Andrew;Damert, Annette;de Jong, Pieter J.;Dumas, Laura;Fernandez-Callejo, Marcos;Flicek, Paul;Fuchs, Nina V.;Gue, Ivo;Gut, Marta;Hahn, Matthew W.;Hernandez-Rodriguez, Jessica;Hillier, LaDeana W.;Hubley, Robert;Ianc, Bianca;Izsvak, Zsuzsanna;Jablonski, Nina G.;Johnstone, Laurel M.;Karimpour-Fard, Anis;Konkel, Miriam K.;Kostka, Dennis;Lazar, Nathan H.;Lee, Sandra L.;Lewis, Lora R.;Liu, Yue;Locke, Devin P.;Mallick, Swapan;Mendez, Fernando L.;Muffato, Matthieu;Nazareth, Lynne V.;Nevonen, Kimberly A.;O'Bleness, Majesta;Ochis, Cornelia;Odom, Duncan T.;Pollard, Katherine S.;Quilez, Javier;Reich, David;Rocchi, Mariano;Schumann, Gerald G.;Searle, Stephen;Sikela, James M.;Skollar, Gabriella;Smit, Arian;Sonmez, Kemal;ten Hallers, Boudewijn;Terhune, Elizabeth;Thomas, Gregg W. C.;Ullmer, Brygg;Ventura, Mario;Walker, Jerilyn A.;Wall, Jeffrey D.;Walter, Lutz;Ward, Michelle C.;Wheelan, Sarah J.;Whelan, Christopher W.;White, Simon;Wilhelm, Larry J.;Woerner, August E.;Yandell, Mark;Zhu, Baoli;Hammer, Michael F.;Marques-Bonet, Tomas;Eichler, Evan E.;Fulton, Lucinda;Fronick, Catrina;Muzny, Donna M.;Warren, Wesley C.;Worley, Kim C.;Rogers, Jeffrey;Wilson, Richard K.;Gibbs, Richard A.
长臂猿是小型树栖类人猿，其染色体重排的进化速度加快，在旧大陆猴和类人猿之间的灵长类动物进化史中占据关键节点。在这里，我们提出了组装和分析的北方白颊长吻鳕（Nomelleucogenys）的基因组。我们描述了一个gibbon特异性反转录转座子（LAVA）插入染色体分离基因和改变转录的倾向，通过提供一个提前终止位点，这表明一个可能的分子机制的gibbon血统的基因组可塑性。我们进一步表明，giblium属（诺姆，Hylobates，Hoolock和Symphalangus）经历了近500万年前的瞬时辐射，与东南亚的主要地理变化相吻合，导致栖息地压缩和扩张的周期。最后，我们确定了积极的选择在前肢发育（TBX 5）和结缔组织（COL 1A 1），可能参与了长臂猿的适应他们的树栖栖息地的基因的签名。本文的在线版本（doi：10.1038/nature 13679）包含补充材料，可供授权用户使用。基因组的gills，树居猿从亚洲之间的旧大陆的猴子和大猿，定位，提供深入了解gills物种的进化历史和他们的加速核型，以及证据选择的基因，如前肢发育和结缔组织，可能是重要的运动通过树木。本文的在线版本（doi：10.1038/nature 13679）包含补充材料，可供授权用户使用。许多种类的长臂猿都是来自东南亚的小型树栖类人猿，它们中的大多数在IUCN名单上被列为“濒危”或“极度濒危”。在他们对北方白颊长臂猿（Nomeleucogenys）基因组的展示中，露西娅·卡伯恩（Lucia Carbone）和同事们对一个跨越旧大陆猴子和类人猿之间鸿沟的群体的生物学和进化史提供了有趣的见解。作者研究了一种新的长臂猿特异性反转录转座子如何成为长臂猿基因组可塑性的来源。快速的核型进化与气候和环境变化的多个事件相结合，可能解释了四个属几乎瞬间的分歧。对前肢发育和结缔组织相关基因的正选择可能与长臂猿在热带树冠中独特的运动方式有关。本文的在线版本（doi：10.1038/nature 13679）包含补充材料，可供授权用户使用。
Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we present the assembly and analysis of a northern white-cheeked gibbon (Nomascus leucogenys) genome. We describe the propensity for a gibbon-specific retrotransposon (LAVA) to insert into chromosome segregation genes and alter transcription by providing a premature termination site, suggesting a possible molecular mechanism for the genome plasticity of the gibbon lineage. We further show that the gibbon genera (Nomascus, Hylobates, Hoolock and Symphalangus) experienced a near-instantaneous radiation ∼5 million years ago, coincident with major geographical changes in southeast Asia that caused cycles of habitat compression and expansion. Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat. The online version of this article (doi:10.1038/nature13679) contains supplementary material, which is available to authorized users. The genome of the gibbon, a tree-dwelling ape from Asia positioned between Old World monkeys and the great apes, is presented, providing insights into the evolutionary history of gibbon species and their accelerated karyotypes, as well as evidence for selection of genes such as those for forelimb development and connective tissue that may be important for locomotion through trees. The online version of this article (doi:10.1038/nature13679) contains supplementary material, which is available to authorized users. The many species of gibbons are small, tree-living apes from Southeast Asia, most of them listed as 'endangered' or 'critically endangered' on the IUCN list. In their presentation of the genome of the northern white-cheeked gibbon (Nomascus leucogenys) , Lucia Carbone and colleagues provide intriguing insights into the biology and evolutionary history of a group that straddles the divide between Old World monkeys and the great apes. The authors investigate how a novel gibbon-specific retrotransposon might be the source of gibbons' genome plasticity. Rapid karyotype evolution combined with multiple episodes of climate and environmental change might explain the almost instantaneous divergence of the four gibbon genera. Positive selection on genes involved in forelimb development and connective tissue might have been related to gibbons' unique mode of locomotion in the tropical canopy. The online version of this article (doi:10.1038/nature13679) contains supplementary material, which is available to authorized users.
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影响因子：
3.3
作者：
Carbone L;Harris RA;Mootnick AR;Milosavljevic A;Martin DI;Rocchi M;Capozzi O;Archidiacono N;Konkel MK;Walker JA;Batzer MA;de Jong PJ
通讯作者：
de Jong PJ
影响因子：
2
作者：
Browne, Marilyn L.;Carter, Tonia C.;Mills, James L.
通讯作者：
Mills, James L.
影响因子：
64.8
作者：
Li, Heng;Durbin, Richard
通讯作者：
Durbin, Richard
影响因子：
4.5
作者：
Carbone L;Vessere GM;ten Hallers BF;Zhu B;Osoegawa K;Mootnick A;Kofler A;Wienberg J;Rogers J;Humphray S;Scott C;Harris RA;Milosavljevic A;de Jong PJ
通讯作者：
de Jong PJ
影响因子：
56.9
作者：
Gibbs, Richard A.;Rogers, Jeffrey;Zwieg, Ann S.
通讯作者：
Zwieg, Ann S.